Investigation of Some 3H-quinazolin-4-one derivatives in vitro antimicrobial effect and cytotoxicity on human gingival fibroblasts

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dc.contributor.authorDemirel, Ural Ufuk
dc.contributor.authorYılmaz, Aydan
dc.contributor.authorTürkdağı, Hatice
dc.contributor.authorÖztürk, Bahadır
dc.contributor.authorArslan, Uğur
dc.date.accessioned2021-05-15T11:34:13Z
dc.date.available2021-05-15T11:34:13Z
dc.date.issued2019
dc.departmentEczacılık Fakültesi, Farmasötik Kimya Anabilim Dalıen_US
dc.descriptionOzturk, Bahadir/0000-0003-2654-7621
dc.description.abstractThe aim of this study is to synthesize and investigate antimicrobial and cytotoxic activity of 3 H-quinazolinone (1), and its derivatives, which are 3-(4-hydroxyphenyl)-3,4-dihydroquinazolin-4-one (2), 3-(3-hydroxyphenyl)-3,4-dihydroquinazolin-4-one (3), 3-(pyridin-3-ylmethy)-3,4-dihydroquinazolin-4-one (4) and derivatives of 2-methyl-3H-quinazolinone, which are 2-methyl-3-phenyl-3,4-dihydroquinazolin-4-one (6), 2-methyl-3(4-hydroxyphenyl)-3,4- dihydroquinazolin-4-one (7), 2-methyl-3(4-nitrophenyl)-3,4-dihydroquinazolin-4-one (8), compounds. Compounds 2 and 3 were synthesized newly. All compounds were characterized via infrared, H-1-NMR, C-13-NMR, elemental and mass spectral analysis. The compounds were screened for their antimicrobial activity in vitro against E. faecalis ATCC 29212, P. aeruginosa ATCC 27853, S. aureus ATCC 29213, E. Coli ATCC 25922 bacteria and compared with commercial antibiotics (Ampicillin and Gentamicin). The determination of the antimicrobial activity was done by using the broth microdilution methods. The antimicrobial test results indicated that the compounds (1, 4, 6, and 8) have MIC values against P. aeruginosa ATCC 27853 lower than ampicillin. But clear cytotoxic effects on proliferation of the gingival fibroblasts applications were observed in 1, 4, 6, and 8 when compared to the control group.en_US
dc.description.sponsorshipResearch Foundation of Selcuk University, Konya-TurkeySelcuk University [BAP 2011/11201014]en_US
dc.description.sponsorshipWe thank the Research Foundation of Selcuk University, Konya-Turkey (BAP 2011/11201014) for financial support of this work produced from a part of U.U. Demirel's MS Thesis.en_US
dc.identifier.doi10.1080/10406638.2019.1689513
dc.identifier.issn1040-6638
dc.identifier.issn1563-5333
dc.identifier.scopus2-s2.0-85075060957
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1080/10406638.2019.1689513
dc.identifier.urihttps://hdl.handle.net/20.500.12939/296
dc.identifier.wosWOS:000496095800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorDemirel, Ural Ufuk
dc.language.isoen
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofPolycyclic Aromatic Compounds
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibacterialen_US
dc.subjectCytotoxicityen_US
dc.subjectGingival Fibroblasten_US
dc.subjectQuinazolinoneen_US
dc.titleInvestigation of Some 3H-quinazolin-4-one derivatives in vitro antimicrobial effect and cytotoxicity on human gingival fibroblasts
dc.typeArticle

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