Vitamin D Receptor Polymorphisms in Overweight/Obese Chronic Kidney Disease Patients on Dialysis

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dc.contributor.authorBagci, Gokhan
dc.contributor.authorHuzmeli, Can
dc.contributor.authorBagci, Binnur
dc.contributor.authorCandan, Ferhan
dc.date.accessioned2025-02-06T17:58:18Z
dc.date.available2025-02-06T17:58:18Z
dc.date.issued2024
dc.departmentAltınbaş Üniversitesien_US
dc.description.abstractBackground: Little is known about the possible association of vitamin D receptor (VDR) gene polymorphisms in obese patients with chronic kidney disease on dialysis (CKD-G5D). Therefore, we aimed to investigate VDR gene TaqI, ApaI, and FokI single-nucleotide polymorphisms (SNPs) in overweight/obese CKD-G5D patients. Methods: Seventy-one normal-weight and 68 overweight/obese CKD-G5D patients were included in the study. The polymerase chain reaction-restriction fragment length polymorphism method was used for genotyping. Demographic and laboratory data were obtained from the medical records of patients. Results: For all 3 SNPs, no significant association was found between normal-weight and overweight/obese patients ( P > .05). High-density lipoprotein (HDL) concentrations were lower, but triglyceride (TG) and glucose levels were higher in overweight/obese patients compared to normal-weight patients ( P < .001 for HDL and TG and P = .023 for glucose). In overweight/obese patients, individuals with the TaqI CC genotype had higher (PTH) levels than those with TC and TT genotypes (CC = 717.1 +/- 616.4, TC = 342.7 +/- 360.8, and TT = 310.2 +/- 323.4 pg/mL; P = .028). Similarly, patients with the ApaI genotype (627.3 +/- 653.0 mg/dL) had higher TG levels than those with the AA and AC genotypes (CC = 627.3 +/- 653.0, AA = 223.3 +/- 156.6, AC = 193.1 +/- 85.4; P < .001). Overweight/obese patients with the FokI TT genotype had higher glucose concentrations than those with the CC and CT genotypes (CC = 183.4 +/- 128.4 mg/dL, TT = 151.9 +/- 66.1 mg/dL, and CT = 107.6 +/- 41.9 mg/dL; P = .008). Conclusion: Our study suggests that VDR TaqI, ApaI, and FokI polymorphisms are not associated with obesity in CKD-G5D patients. However, they might increase the risk of secondary hyperparathyroidism, dyslipidemia, and hyperglycemia.en_US
dc.identifier.doi10.5152/turkjnephrol.2023.23369
dc.identifier.issn2667-4440
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.trdizinid1267463
dc.identifier.urihttps://doi.org/10.5152/turkjnephrol.2023.23369
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1267463
dc.identifier.urihttps://hdl.handle.net/20.500.12939/5164
dc.identifier.volume33en_US
dc.identifier.wosWOS:001236262600016
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.publisherAVESen_US
dc.relation.ispartofTurkish Journal of Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKA_WOS_20250206
dc.subjectCKD-G5Den_US
dc.subjecthemodialysisen_US
dc.subjectobesityen_US
dc.subjectpolymorphismen_US
dc.subjectvitamin D receptoren_US
dc.titleVitamin D Receptor Polymorphisms in Overweight/Obese Chronic Kidney Disease Patients on Dialysisen_US
dc.typeArticleen_US

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