THE USE OF ACTIVIN IN OVARIAN FOLLICLE CULTURE SYSTEMS

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dc.contributor.authorTepekoy, Filiz
dc.date.accessioned2025-02-06T18:01:23Z
dc.date.available2025-02-06T18:01:23Z
dc.date.issued2020
dc.departmentAltınbaş Üniversitesien_US
dc.description.abstractThe cancer treatment during puberty and early adulthood might have negative effects on reproductive system in women, causing premature menopause, premature ovarian failure and infertility. In order to protect germ cells from these undesirable effects without any functional loss, different experimental approaches have been developed. One of these approaches is ovarian follicle culture system which includes in vitro growth of ovarian follicles obtained from the patients before being exposed to the detrimental effects of cancer treatment. In vitro growth of the follicles starts from primordial stage and gives rise to an ovulatory follicle with a competent oocyte within a culture system supplemented with folliculogenesis activators. Activin is one of these follicle activators supporting the growth and survival of the follicles. As a member of the transforming growth factor beta (TGF-β) superfamily, activin is known to be expressed in granulosa cells and oocytes. The main role of activin is stimulation of follicle stimulating hormone (FSH) secretion from anterior pituitary and induction of follicle growth enabling granulosa cell proliferation and antral cavity formation. Exogenous activin has been considered to be one of the key components of the in vitro follicle culture. The effects of the activin during in vitro follicle growth have been evaluated through both morphological and molecular biological criteria such as oocyte and follicle diameter, oocyte integrity, expressions of proliferation markers in granulosa cells and expressions of mitogenactivated protein kinase (MAPK) and Akt signaling members in the follicles, meiotic competence of oocytes and hormone synthesis. Since, one of the most important effects of activin on granulosa cells is induction of FSH receptor expression, activin is mostly used in combination with FSH during the culture. The current literature has mainly focused on the differential effects of activin on in vitro grown follicles at different developmental stages in the presence and absence of other activators such as FSH. This review covers the key literature on the structural and functional effects of the use of activin during in vitro growth of ovarian follicles. © 2020 by Nova Science Publishers, Inc. All rights reserved.en_US
dc.identifier.endpage223en_US
dc.identifier.isbn978-153617452-6
dc.identifier.isbn978-153617451-9
dc.identifier.scopus2-s2.0-85138413097
dc.identifier.startpage211en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/5373
dc.identifier.volume160en_US
dc.indekslendigikaynakScopus
dc.institutionauthorTepekoy, Filiz
dc.language.isoenen_US
dc.publisherNova Science Publishers, Inc.en_US
dc.relation.ispartofAdvances in Medicine and Biology: Volume 160en_US
dc.relation.publicationcategoryKitap Bölümü - Uluslararasıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_Scopus_20250206
dc.subjectActivinen_US
dc.subjectFollicle cultureen_US
dc.subjectOocyte maturationen_US
dc.subjectOvaryen_US
dc.titleTHE USE OF ACTIVIN IN OVARIAN FOLLICLE CULTURE SYSTEMSen_US
dc.typeBook Parten_US

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