Optimization of dexketoprofen trometamol tablet formulations utilizing different modeling techniques and the quality by design

Basit Öğe Kaydı
dc.contributor.authorDemir, Önder
dc.contributor.authorAksu, Buket
dc.contributor.authorÖzsoy, Yıldız
dc.contributor.authorAraman, Ahmet
dc.date.accessioned2021-05-15T12:37:10Z
dc.date.available2021-05-15T12:37:10Z
dc.date.issued2016
dc.departmentEczacılık Fakültesien_US
dc.descriptionAksu, Buket/0000-0001-7555-0603
dc.description.abstractDexketoprofen trometamol is a sensitive molecule and consists of a fine, poor flowing, extremely adhesive powder that leaves behind gummed residue on the punch surface of the tablet press machine. The purpose of this study is to determine the optimum formulation utilizing different modeling techniques and the Quality by Design (QbD) approach without sticking problem during production. General full factorial design of experiments (DoE) was formed and the raw experimental data were evaluated using Minitab, artificial neural network (ANN) and gene expression programming (GEP) modules of the INForm. The Minitab, ANN and GEP modeling programs suggested the optimum formulations that should contain 2.03% and 2.50% glyceryl dibehenate by applying slug compression. However, in trial studies, the only lubricant that resolves the sticking problem was sodium stearyl fumarate. Therefore, new optimum formula trials have been performed by employing sodium stearyl fumarate at the same percentages instead of glyceryl dibehenate. All of the optimum formula analysis indicates that quality target product profile (QTPP) was met and the sticking problem was resolved.en_US
dc.identifier.endpage825en_US
dc.identifier.issn0326-2383
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84963535698
dc.identifier.scopusqualityQ4
dc.identifier.startpage813en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/488
dc.identifier.volume35en_US
dc.identifier.wosWOS:000379543300024
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorAksu, Buket
dc.language.isoen
dc.publisherColegio Farmaceuticos Provincia De Buenos Airesen_US
dc.relation.ispartofLatin American Journal of Pharmacy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDesign Of Experimentsen_US
dc.subjectDexketoprofen Trometamolen_US
dc.subjectINFormen_US
dc.subjectMinitaben_US
dc.subjectQuality By Designen_US
dc.titleOptimization of dexketoprofen trometamol tablet formulations utilizing different modeling techniques and the quality by design
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Eczacılık Fakültesi Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu