Y-90 dosimetry with Monte Carlo method: GATE validation with STL formatted phantom

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dc.contributor.authorKökkülünk, H. Tanyıldızı
dc.contributor.authorDemir, M.
dc.contributor.authorYıldırım, A. Karadeniz
dc.contributor.authorÖzkorucuklu, S.
dc.contributor.authorAkkuş, B.
dc.contributor.authorYaşar, D.
dc.date.accessioned2021-05-15T11:33:21Z
dc.date.available2021-05-15T11:33:21Z
dc.date.issued2020
dc.departmentSağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Görüntüleme Teknikleri Programıen_US
dc.description.abstractIn Y-90 treatment, it is important to implement patient-specific dosimetry. The study was aimed at creating an STL-based liver model phantom with multiple tumor mimics to test the GATE program and to perform Y-90 dosimetry with the Monte Carlo method. First, the liver model phantom with the outer dimensions of 22 x 14 x 8 cm(3) was made of plexiglass and two cylindrical tumor mimics were placed in it. (99mTc) activities with 62.9 MBq and 7 MBq were placed in both tumor mimics. Thermoluminescent dosimeters were used at 10 positions in the liver model phantom. Next, the same conditions were simulated in GATE and the absorbed doses were determined with DoseActors. After GATE validation, the absorbed doses were calculated for Y-90 source of 40.7 MBq. Based on this, the absorbed doses were estimated for the average amount of therapeutic Y-90 activity. The average instant absorbed doses in the liver model phantom for Tc-99m activities were found to be between 0.337 +/- 0.002 and 0.0059 +/- 0.0008 mu Gy/s via thermoluminescent dosimeters and between 0.367 +/- 0.002 and 0.0052 +/- 0.0003 mu Gy/s via GATE. When the Tc-99m results were compared, the mean overlap ratio and R-squared value were 10.68% and 0.9966, respectively. The mean absorbed doses in the first tumor mimic, the second tumor mimic and normal liver parenchymal tissue were 1350.0 +/- 7:7, 450.0 +/- 4.4 and 3.9 +/- 0.2 Gy for 1480 MBq therapeutic Y-90 activity. The GATE simulation showed significantly similar dosimetric results with the thermoluminescent dosimeter measurement for a liver dose calculation. As the tumor and liver dose estimation is a key limiting factor in Y-90 dosimetry, the practical application of the GATE simulation is an advantage for dose calculations and can improve the dosimetry.en_US
dc.identifier.doi10.12693/APhysPolA.138.801
dc.identifier.endpage808en_US
dc.identifier.issn0587-4246
dc.identifier.issn1898-794X
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85099251557
dc.identifier.scopusqualityQ3
dc.identifier.startpage801en_US
dc.identifier.urihttps://doi.org/10.12693/APhysPolA.138.801
dc.identifier.urihttps://hdl.handle.net/20.500.12939/140
dc.identifier.volume138en_US
dc.identifier.wosWOS:000608139200008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorKökkülünk, H. Tanyıldızı
dc.language.isoen
dc.publisherPolish Acad Sciences Inst Physicsen_US
dc.relation.ispartofActa Physica Polonica A
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRadionuclide Dosimetryen_US
dc.subjectMonte Carlo Methoden_US
dc.subjectGATEen_US
dc.subjectY-90en_US
dc.titleY-90 dosimetry with Monte Carlo method: GATE validation with STL formatted phantom
dc.typeArticle

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