Morphological changes of trichomonas vaginalis treated by ornidazole: An in-vitro study

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dc.contributor.authorÇakan, Hüseyin
dc.contributor.authorPolat, Erdal
dc.contributor.authorArda, Oktay
dc.contributor.authorCepni, İsmail
dc.contributor.authorDirican, Ahmet
dc.contributor.authorSirekbasan, Serhat
dc.date.accessioned2021-05-15T12:37:26Z
dc.date.available2021-05-15T12:37:26Z
dc.date.issued2016
dc.departmentTıp Fakültesi, Embriyoloji Anabilim Dalıen_US
dc.descriptionDIRICAN, AHMET/0000-0001-8454-4547; Sirekbasan, Serhat/0000-0001-7967-3539; Cakan, Huseyin/0000-0003-0574-3578; cepni, ismail/0000-0003-3543-8849
dc.description.abstractBackground: Nitroimidazoles, which are drugs that are used to effectively treat Trichomonas vaginalis, alter the structure of the T. vaginalis cell membrane, penetrate into its cytoplasm and nucleus and block cellular metabolism. In this study, we observed the morphological changes that occurred in T. vaginalis during in vitro exposure to 1.3 mu g/mL of ornidazole at various time intervals ranging from 10 minutes to 10 hours. Methods: Vaginal and urethral secretion samples from suspected T. vaginalis cases were inoculated into Cysteine Peptone Liver Maltose medium. In 18 sterile tubes, 9.5 mL of this solution were mixed with 0.5 mL of ornidazole. The periods of contact between ornidazole and T. vaginalis ranged from 10 minutes to 10 hours. Results: The first change was vacuolization, which started in the 10th minute of exposure. The glycogen particles started to diminish in the 20th minute. Conclusions: During exposure to 1.3 mg/L of ornidazole, cell lysis began in the 30th minute and accelerated towards the 60th minute (p < 0.001). Cytoplasmic matrix integrity was impaired in the 60th minute (p < 0.001).en_US
dc.identifier.doi10.7754/Clin.Lab.2015.150731
dc.identifier.endpage800en_US
dc.identifier.issn1433-6510
dc.identifier.issue5en_US
dc.identifier.pmid27349003
dc.identifier.startpage793en_US
dc.identifier.urihttps://doi.org/10.7754/Clin.Lab.2015.150731
dc.identifier.urihttps://hdl.handle.net/20.500.12939/534
dc.identifier.volume62en_US
dc.identifier.wosWOS:000375968300006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorArda, Oktay
dc.language.isoen
dc.publisherClin Lab Publen_US
dc.relation.ispartofClinical Laboratory
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectT. Vaginalisen_US
dc.subjectOrnidazoleen_US
dc.subjectIn-Vivo Activityen_US
dc.subjectUltrastructureen_US
dc.subjectVacuolizationen_US
dc.subjectGlycogen Particlesen_US
dc.titleMorphological changes of trichomonas vaginalis treated by ornidazole: An in-vitro study
dc.typeArticle

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