Biodegradable polysaccharide aerogels based on tragacanth and alginate as novel drug delivery systems

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dc.contributor.authorAl-barudi, Amenah
dc.contributor.authorSinani, Genada
dc.contributor.authorÜlker, Zeynep
dc.date.accessioned2024-02-20T12:26:23Z
dc.date.available2024-02-20T12:26:23Z
dc.date.issued2024en_US
dc.departmentFakülteler, Eczacılık Teknolojisi Bilimleri Bölümü, Farmasötik Teknoloji Ana Bilim Dalıen_US
dc.description.abstractTragacanth, an anionic polysaccharide, is a natural material widely investigated for the synthesis of aerogels as drug delivery vehicles. Its biocompatibility, biodegradability, and affordability are all key features for its use in pharmaceutical applications. In this study, tragacanth and tragacanth alginate composite aerogels were prepared using the sol-gel technique followed by supercritical drying. Paracetamol was selected as a model drug for drug loading and release studies owing to its high solubility in ethanol and low solubility in supercritical carbon dioxide. The paracetamol loading into the aerogel pores was confirmed by infrared spectroscopy (IR) and x-ray diffraction (XRD) spectra of the resulting samples. Scanning electron microscopy (SEM) images showed that all aerogels were porous with a macroporous-mesoporous network. Due to the high porosity of the prepared aerogels, a loading of 99 wt% (mg drug/mg aerogel) for tragacanth and 114 wt% (mg drug/mg aerogel) for composite aerogels was achieved. Moreover, the release rate of the drug could be modified by manipulating the aerogel composition. Tragacanth aerogels had a faster release rate, while the addition of alginate prolonged the release rate of the model drug. Various empirical release models were investigated and the release rate was found to follow the Korsmeyer-Peppas (Power Law) model suggesting a diffusion-based release kinetics. Based on the results, the feasibility of utilizing tragacanth for the preparation of drug-loaded aerogels was shown. Tragacanth is a suitable polysaccharide for the synthesis of aerogels.Macropores/mesopores of all synthesized aerogels are suitable for drug loading.The presence of alginate retards the release of the model drug up to 20% at each time point.The release kinetics of the synthesized aerogels follow the Korsmeyer-Peppas model.en_US
dc.identifier.citationAl-barudi, A., Sinani, G., Ulker, Z. (2023). Biodegradable polysaccharide aerogels based on tragacanth and alginate as novel drug delivery systems. Journal of Sol-Gel Science and Technology. 10.1007/s10971-024-06312-0en_US
dc.identifier.issn0928-0707
dc.identifier.issn1573-4846
dc.identifier.scopus2-s2.0-85183685626
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://hdl.handle.net/20.500.12939/4602
dc.identifier.wosWOS:001152775400001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorSinani, Genada
dc.institutionauthorÜlker, Zeynep
dc.language.isoen
dc.relation.ispartofJournal of Sol-Gel Science and Technology
dc.relation.isversionof10.1007/s10971-024-06312-0en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAerogelen_US
dc.subjectTragacanthen_US
dc.subjectAlginateen_US
dc.subjectSupercritical dryingen_US
dc.subjectDrug delivery systemen_US
dc.subjectRelease kineticsen_US
dc.titleBiodegradable polysaccharide aerogels based on tragacanth and alginate as novel drug delivery systems
dc.typeArticle

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