Oral cavity beta-defensin levels are regulated differently during radiotherapy in head and neck cancer patients

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dc.contributor.authorKeskin, Mutlu
dc.contributor.authorSuomi, Emma
dc.contributor.authorHarmankaya, İlknur
dc.contributor.authorKaraçetin, Didem
dc.contributor.authorSorsa, Timo
dc.contributor.authorGürsoy, Ulvi Kahraman
dc.date.accessioned2023-03-16T08:38:25Z
dc.date.available2023-03-16T08:38:25Z
dc.date.issued2023en_US
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Ağız ve Diş Sağlığı Programıen_US
dc.description.abstractBackground: Human beta-defensins (hBDs) are small cationic peptides of the epithelium with broad antimicrobial and immune response-regulatory activities. hBDs are also related to oncogenesis, and their secretion profiles are affected by radiotherapy treatment. The present study aimed to investigate the oral cavity hBD 1-3 levels in head and neck cancer patients and its relation to radiotherapy treatment. Methods: Sixteen head and neck cancer patients (all with a history of smoking) were included in this study. Periodontal parameters were measured before radiotherapy, and medical information was collected from registries. Oral rinses of the patients were collected before radiotherapy; on the 1st, 3rd, and 6th weeks of radiotherapy; and the 1st month following the end of radiotherapy. hBD 1–3 levels were measured using ELISA. Results: Oral hBD-1 levels increased during radiotherapy at week 6 (p = 0.019). hBD-1 levels returned to pretreatment levels after the end of radiotherapy. No significant change was detected for hBD-2 or hBD-3 levels during or after radiotherapy. Conclusions: The constant expression of hBD-1, which is distinct from the infection and inflammation-dependent expression profiles of hBD-2 and hBD-3, may explain why this peptide is the only one affected by radiotherapy.en_US
dc.identifier.citationKeskin, M., Suomi, E., Harmankaya, İ., Karaçetin, D., Sorsa, T., & Gürsoy, U. K. (2023). Oral cavity beta-defensin levels are regulated differently during radiotherapy in head and neck cancer patients. Applied Sciences, 13(4), 2056.en_US
dc.identifier.issn2076-3417
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85149320397
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/20.500.12939/3443
dc.identifier.volume13en_US
dc.identifier.wosWOS:000938212300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorKeskin, Mutlu
dc.language.isoen
dc.publisherMDPIen_US
dc.relation.ispartofApplied Sciences (Switzerland)
dc.relation.isversionof10.3390/app13042056en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHead And Neck Canceren_US
dc.subjectHuman Beta-Defensinsen_US
dc.subjectRadiotherapyen_US
dc.titleOral cavity beta-defensin levels are regulated differently during radiotherapy in head and neck cancer patients
dc.typeArticle

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