Neuroprotective effects of wharton jelly stem cell-derived exosomes developed as nano-drug delivery system in 6-OHDA-induced neurotoxicity in 2D and 3D neuronal cell line

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dc.contributor.authorYavuz, Burçak
dc.contributor.authorYıldız, Aslı Pınar Zorba
dc.contributor.authorAbamor, Emrah Sefik
dc.contributor.authorDarıcı, Hakan
dc.contributor.authorAllahverdiyev, Adil M.
dc.date.accessioned2023-12-03T12:51:05Z
dc.date.available2023-12-03T12:51:05Z
dc.date.issued2023en_US
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Görüntüleme Teknikleri Programıen_US
dc.description.abstractPurpose: The underlying mechanism of today’s neurodegenerative diseases is disordered due to neuronal damage and very limited neuronal regeneration. Formulations that can be developed against the factors that cause damage must have a neuroprotective effect. Particularly, formulations that can be developed in nanoscales may play a key role in central nervous system diseases. This article aimed to investigate the neuroprotective activity of dopamine-loaded exosomes in which exosomes derived from Wharton jelly stem cells (WJ-MSCs) are used as carrier systems in 2D and 3D cell cultures induced in cell damage. Materials and Methods: This study created 2D and 3D cell cultures with a bioprinter in the dopaminergic neuroblastoma cell line (SH-SY5Y). Cell lines were damaged with 6-OHDA. The neuroprotective effect of dopamine-loaded exosomes was investigated by Live&Dead analysis and immunostaining. Results: The findings showed that dopamine-loaded exosomes protected against 6-OHDA-induced neurotoxicity in both cultures. The increase in the number of viable cells in the 6-OHDA administered groups proved the neuroprotective effect. Conclusion: We predict that the carrier systems developed with exosomes obtained from Wharton jelly stem cells will be a light of hope in the treatment of neurodegenerative diseases, considering both their size and their contribution to regeneration. Lay Summary: Especially in neurodegenerative diseases, it is very important to be able to protect and regenerate neurons. Wharton jelly stem cell-based exosomes are known to have many properties, including other wound healing activities. In addition, considering both the structure and size of exosomes, its development as a drug delivery system is promising.en_US
dc.identifier.citationYavuz, B., Yıldız, A. P. Z., Abamor, E. S., Darıcı, H., Allahverdiyev, A. M. (2023). Neuroprotective effects of wharton jelly stem cell-derived exosomes developed as nano-drug delivery system in 6-OHDA-induced neurotoxicity in 2D and 3D neuronal cell line. Regenerative Engineering and Translational Medicine.en_US
dc.identifier.issn2364-4133
dc.identifier.scopus2-s2.0-85176791243
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://hdl.handle.net/20.500.12939/4255
dc.identifier.wosWOS:001102567700001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer Science and Business Media Deutschland GmbHen_US
dc.relation.ispartofRegenerative Engineering and Translational Medicine
dc.relation.isversionof10.1007/s40883-023-00322-0en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject3D cell cultureen_US
dc.subjectDrug delivery systemen_US
dc.subjectExosomeen_US
dc.subjectNeuroprotective effectsen_US
dc.subjectRegenerative medicineen_US
dc.subjectWharton jelly stem cellen_US
dc.titleNeuroprotective effects of wharton jelly stem cell-derived exosomes developed as nano-drug delivery system in 6-OHDA-induced neurotoxicity in 2D and 3D neuronal cell line
dc.typeArticle

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