Chemical composition and in vitro cytotoxicity of Cyclotrichium niveum essential oil against human breast adenocarcinoma (MCF-7) and human lung adenocarcinoma (A549) cells
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Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Har Krishan Bhalla and Sons
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The current study is aimed to investigate the essential oil yields, chemical compositions and in vitro cytotoxic activities of Cyclotrichium niveum (Boiss.) Manden et Scheng. C. niveum is an endemic species of Turkiye, generally used as a spice in local cuisine and traditional medicine. The plant material was collected from Yeşilyurt province of Malatya in August. Hydrodistillation yielded 1.41% (g/g) essential oil. The majority of the essential oil was dominated by oxygenated monoterpenes mainly pulegone (56.83%) and isomenthone (29.06%). Cytotoxicity tests of C. niveum essential oil on MCF-7 (human breast adenocarcinoma cells) and A549 (human lung adenocarcinoma alveolar basal epithelial cells) cell lines represented promising results. IC50 values on MCF-7 and A549 were found to be 31.68 μg/mL and 66.70 μg/mL respectively. In the current work, we have shown for the first time that C. niveum essential oil has cytotoxic properties in the cancer cell lines tested.
Açıklama
Anahtar Kelimeler
A549, Cyclotrichium niveum, Cytotoxicity, Essential oil, MCF-7
Kaynak
Journal of Essential Oil-Bearing Plants
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
26
Sayı
4
Künye
Demirbolat, I., Karık, Ü., Nath, E. Ö., Abudayyak, M., & Kartal, M. (2023). Chemical composition and in vitro cytotoxicity of Cyclotrichium niveum essential oil against human breast adenocarcinoma (MCF-7) and human lung adenocarcinoma (A549) cells. Journal of Essential Oil Bearing Plants, 26(4), 830-835.
