Chemical composition and in vitro cytotoxicity of Cyclotrichium niveum essential oil against human breast adenocarcinoma (MCF-7) and human lung adenocarcinoma (A549) cells

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dc.contributor.authorDemirbolat, İlker
dc.contributor.authorKarık, Ünal
dc.contributor.authorNath, Ebru Özdemir
dc.contributor.authorAbudayyak, Mahmoud
dc.contributor.authorKartal, Murat
dc.date.accessioned2023-11-07T12:19:01Z
dc.date.available2023-11-07T12:19:01Z
dc.date.issued2023en_US
dc.departmentFakülteler, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Botanik Ana Bilim Dalıen_US
dc.description.abstractThe current study is aimed to investigate the essential oil yields, chemical compositions and in vitro cytotoxic activities of Cyclotrichium niveum (Boiss.) Manden et Scheng. C. niveum is an endemic species of Turkiye, generally used as a spice in local cuisine and traditional medicine. The plant material was collected from Yeşilyurt province of Malatya in August. Hydrodistillation yielded 1.41% (g/g) essential oil. The majority of the essential oil was dominated by oxygenated monoterpenes mainly pulegone (56.83%) and isomenthone (29.06%). Cytotoxicity tests of C. niveum essential oil on MCF-7 (human breast adenocarcinoma cells) and A549 (human lung adenocarcinoma alveolar basal epithelial cells) cell lines represented promising results. IC50 values on MCF-7 and A549 were found to be 31.68 μg/mL and 66.70 μg/mL respectively. In the current work, we have shown for the first time that C. niveum essential oil has cytotoxic properties in the cancer cell lines tested.en_US
dc.identifier.citationDemirbolat, I., Karık, Ü., Nath, E. Ö., Abudayyak, M., & Kartal, M. (2023). Chemical composition and in vitro cytotoxicity of Cyclotrichium niveum essential oil against human breast adenocarcinoma (MCF-7) and human lung adenocarcinoma (A549) cells. Journal of Essential Oil Bearing Plants, 26(4), 830-835.en_US
dc.identifier.endpage835en_US
dc.identifier.issn0972-060X
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85173762345
dc.identifier.scopusqualityQ2
dc.identifier.startpage830en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/4212
dc.identifier.volume26en_US
dc.indekslendigikaynakScopus
dc.institutionauthorNath, Ebru Özdemir
dc.institutionauthorAbudayyak, Mahmoud
dc.language.isoen
dc.publisherHar Krishan Bhalla and Sonsen_US
dc.relation.ispartofJournal of Essential Oil-Bearing Plants
dc.relation.isversionof10.1080/0972060X.2023.2255611en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectA549en_US
dc.subjectCyclotrichium niveumen_US
dc.subjectCytotoxicityen_US
dc.subjectEssential oilen_US
dc.subjectMCF-7en_US
dc.titleChemical composition and in vitro cytotoxicity of Cyclotrichium niveum essential oil against human breast adenocarcinoma (MCF-7) and human lung adenocarcinoma (A549) cells
dc.typeArticle

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