The wear-off phenomenon of repeated botulinum toxin injection for chronic migraine treatment: A retrospective study

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dc.contributor.authorRuşen, Emir
dc.contributor.authorHafez, Gaye
dc.contributor.authorTunç, Yeşim
dc.date.accessioned2024-05-27T13:05:50Z
dc.date.available2024-05-27T13:05:50Z
dc.date.issued2024en_US
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalıen_US
dc.description.abstractObjectives: This study aimed to evaluate the efficacy, predictors of response, clinical considerations, and analysis of patient-reported wear-off events during injection periods of onabotulinumtoxinA (Onabot-A). Patients and methods: This retrospective study was conducted with 30 adult chronic migraine patients (26 females, 4 males; mean age: 37.9±9.3 years; range, 24 to 72 years) followed between January 2017 and December 2022. All patients received Onabot-A injections at different frequencies throughout their treatment and responded to Onabot-A. The duration between cycles was 3 months in 26 patients, and this period varied in four patients. The Visual Analog Scale scores were measured before and after the injection, all patients responded to Onabot-A. Results: Nine patients stated that they experienced wear-off at least once during their treatment cycles. In some patients, the duration of action lasted less than 12 weeks, resulting in a wear-off phenomenon. Although sex and age were not significant variables in terms of the presence or absence of wear-off phenomenon, the number of Onabot-A injections (Onabot-A treatment cycles) among patients was found to be a statistically significant variable in terms of the presence of wear-off (p<0.011). Conclusion: Repeated treatments using Onabot-A appear to be safe and well-tolerated, but the effectiveness of the drug appears to be affected by wear-off phases that may occur during long-term treatment with Onabot-A.en_US
dc.identifier.citationRuşen, E., Hafez, G., Tunç, Y. (2024). The wear-off phenomenon of repeated botulinum toxin injection for chronic migraine treatment: A retrospective study. Türk Nöroloji Dergisi, 30(1), 47-55. 10.55697/tnd.2024.18en_US
dc.identifier.endpage55en_US
dc.identifier.issn1301-062X
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85192919292
dc.identifier.scopusqualityN/A
dc.identifier.startpage47en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/4706
dc.identifier.volume30en_US
dc.indekslendigikaynakScopus
dc.institutionauthorRuşen, Emir
dc.institutionauthorHafez, Gaye
dc.language.isoen
dc.publisherTurkish Neurosurgical Societyen_US
dc.relation.ispartofTürk Nöroloji Dergisi
dc.relation.isversionof10.55697/tnd.2024.18en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBotulinum toxinen_US
dc.subjectHeadacheen_US
dc.subjectMigraineen_US
dc.subjectOnabot-Aen_US
dc.subjectWear-offen_US
dc.titleThe wear-off phenomenon of repeated botulinum toxin injection for chronic migraine treatment: A retrospective study
dc.title.alternativeKronik migren tedavisinde tekrarlanan botulinum toksin enjeksiyonunun yıpranma payı (wear-off fenomeni): Retrospektif çalışma
dc.typeArticle

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