Essential oil composition of Isatis floribunda Boiss. ex. Bornm. and acetylcholinesterase inhibitory activity of its extract
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Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Istanbul Medipol University
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
This study aims to investigate the essential oil composition of aerial parts of Isatis floribunda, and the acetylcholinesterase inhibitory activity of its extracts. Essential oil of the aerial parts of the plant material was obtained and the GC-MS analysis was performed. Then, extracts of the plant material were obtained, and in vitro acetylcholinesterase inhibitory assay was performed. GC-MS analysis demonstrated that the composition of Isatis floribunda is rich in fatty acid compounds, with the major compounds including dodecanoic acid, nanocosane, hexadecenoic acid, tetradecanoic acid, methyl octadecenoate, decanoic acid, and hexahydrofarnesyl acetone. Methanolic extract of the plant species has demonstrated strong acetylcholinesterase inhibitory activity with the IC50 value of 0.16 mg/mL. Essential oil composition of Isatis floribunda has been determined to be rich in fatty acid components, these compounds could demonstrate potent acetylcholinesterase inhibition. Therefore, a novel medication from Isatis floribunda extracts could be discovered against Alzheimer’s disease.
Açıklama
Anahtar Kelimeler
Acetylcholinesterase inhibition, Brassicaceae, GC-MS, Isatis floribunda
Kaynak
Acta Pharmaceutica Sciencia
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
62
Sayı
3
Künye
Güzel, E., Yücel, Y. Y., Alkan, M., Polatoğlu, K. (2024). Essential oil composition of Isatis floribunda Boiss. ex. Bornm. and acetylcholinesterase inhibitory activity of its extract. Acta Pharmaceutica Sciencia, 62(3), 581-592. 10.23893/1307-2080.APS6237
