Essential oil composition of Isatis floribunda Boiss. ex. Bornm. and acetylcholinesterase inhibitory activity of its extract

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dc.contributor.authorGüzel, Elif
dc.contributor.authorYücel, Yasemin Yücel
dc.contributor.authorAlkan, Mustafa
dc.contributor.authorPolatoğlu, Kaan
dc.date.accessioned2024-08-07T12:28:08Z
dc.date.available2024-08-07T12:28:08Z
dc.date.issued2024en_US
dc.departmentFakülteler, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalıen_US
dc.description.abstractThis study aims to investigate the essential oil composition of aerial parts of Isatis floribunda, and the acetylcholinesterase inhibitory activity of its extracts. Essential oil of the aerial parts of the plant material was obtained and the GC-MS analysis was performed. Then, extracts of the plant material were obtained, and in vitro acetylcholinesterase inhibitory assay was performed. GC-MS analysis demonstrated that the composition of Isatis floribunda is rich in fatty acid compounds, with the major compounds including dodecanoic acid, nanocosane, hexadecenoic acid, tetradecanoic acid, methyl octadecenoate, decanoic acid, and hexahydrofarnesyl acetone. Methanolic extract of the plant species has demonstrated strong acetylcholinesterase inhibitory activity with the IC50 value of 0.16 mg/mL. Essential oil composition of Isatis floribunda has been determined to be rich in fatty acid components, these compounds could demonstrate potent acetylcholinesterase inhibition. Therefore, a novel medication from Isatis floribunda extracts could be discovered against Alzheimer’s disease.en_US
dc.identifier.citationGüzel, E., Yücel, Y. Y., Alkan, M., Polatoğlu, K. (2024). Essential oil composition of Isatis floribunda Boiss. ex. Bornm. and acetylcholinesterase inhibitory activity of its extract. Acta Pharmaceutica Sciencia, 62(3), 581-592. 10.23893/1307-2080.APS6237en_US
dc.identifier.endpage592en_US
dc.identifier.issn1307-2080
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85199385693
dc.identifier.scopusqualityQ3
dc.identifier.startpage581en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/4793
dc.identifier.volume62en_US
dc.indekslendigikaynakScopus
dc.institutionauthorYücel, Yasemin Yücel
dc.institutionauthorPolatoğlu, Kaan
dc.language.isoen
dc.publisherIstanbul Medipol Universityen_US
dc.relation.ispartofActa Pharmaceutica Sciencia
dc.relation.isversionof10.23893/1307-2080.APS6237en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcetylcholinesterase inhibitionen_US
dc.subjectBrassicaceaeen_US
dc.subjectGC-MSen_US
dc.subjectIsatis floribundaen_US
dc.titleEssential oil composition of Isatis floribunda Boiss. ex. Bornm. and acetylcholinesterase inhibitory activity of its extract
dc.typeArticle

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