Donors with hepatitis B surface antigen positivity

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dc.contributor.authorYavuz, H. Asuman
dc.contributor.authorTekin, S.
dc.contributor.authorYüksel, Y.
dc.contributor.authorAteş, I.
dc.contributor.authorYücetin, L.
dc.contributor.authorDemir, M.
dc.contributor.authorDemirbaş, A.
dc.date.accessioned2021-05-15T12:37:48Z
dc.date.available2021-05-15T12:37:48Z
dc.date.issued2015
dc.departmentTıp Fakültesi, Genel Cerrahi ve Nakil Ünitesien_US
dc.description.abstractObjective. There is a still controversy among transplantation centers regarding acceptance of hepatitis B surface antigen (HBsAg)-positive donors for renal transplantation. However, some reports show that these donors can be used under a special protocol. In this study, we compared the clinical and biochemical parameters of patients who received kidneys from HBsAg-positive (group 1) versus other living-related kidney donors (group 2). Materials and Methods. We retrospectively analyzed the outcomes of 2168 living-related renal transplantations performed between December 2008 and April 2014 at Medical Park Hospital Transplantation Center, Antalya, Turkey. One hundred eleven donors were HbsAg-positive (group 1), and 2057 donors were HbsAg-negative (group 2). Group 1 kidney transplantations were undertaken only if the recipient displayed a hepatitis B antibody titer >10 mIU/mL and donor hepatitis B virus DNA was negative. Results. Demographic characteristics; 1-, 2- and 4-year serum creatinine levels; glomerular filtration rates; and liver function test results were similar between the two groups. There were no new hepatitis B virus infections throughout the study period. Acute rejection rates (26/111 in group 1 vs 375/2168 in group 2; P = .887), graft loss (4/111 in group 1 vs 123/2168 in group 2; P = .546), and patient loss (6/111 in group 1 vs 102/2168; P = .132) were similar between the two groups. Conclusion. Our study showed that hepatitis B surface antigen positivity was not a contraindication to living-kidney donation.en_US
dc.identifier.doi10.1016/j.transproceed.2015.04.014
dc.identifier.endpage1314en_US
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.issue5en_US
dc.identifier.pmid26093707
dc.identifier.startpage1312en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2015.04.014
dc.identifier.urihttps://hdl.handle.net/20.500.12939/588
dc.identifier.volume47en_US
dc.identifier.wosWOS:000357066800018
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorTekin, S.
dc.language.isoen
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedings
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDonoren_US
dc.subjectHepatitis Ben_US
dc.subjectHBIGen_US
dc.titleDonors with hepatitis B surface antigen positivity
dc.typeArticle

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