Kidney transplantation from elderly donor

Basit Öğe Kaydı
dc.contributor.authorTekin, S.
dc.contributor.authorYavuz, H. A.
dc.contributor.authorYüksel, Y.
dc.contributor.authorYücetin, L.
dc.contributor.authorAteş, I.
dc.contributor.authorTuncer, M.
dc.contributor.authorDemirbaş, A.
dc.date.accessioned2021-05-15T12:37:48Z
dc.date.available2021-05-15T12:37:48Z
dc.date.issued2015
dc.departmentTıp Fakültesi, Genel Cerrahi ve Nakil Ünitesien_US
dc.description.abstractAim. In recent years, there has been an increase in usage of grafts from advanced-age donors because of the shortage of organ availability. Acceptance of elderly living-kidney donors remains controversial due to the higher incidence of comorbidity and greater risk of postoperative complications. The objective of this study was to evaluate the graft function and patient survival using kidneys from living-related and unrelated donors who were older than 65 years of age. Materials and Methods. From December 2008 until December 2013 we compared the outcomes of 294 patients (mean age, 47.67 +/- 12.4 years; range, 16 to 74 years old) who received grafts from donors >= 65 years old to 2339 patients who received grafts from donors who were younger than 65 years old. Results. We observed no significant differences in sex, time on dialysis, or cold ischemia time between the groups. The recipient ages between two groups were similar. For survival analysis we used the Kaplan-Meier survival estimator. Patient survival at 1, 2, and 3 years was 91.1%, 89.1%, and 88.5%, respectively, for patients transplanted with kidneys from donors >= 65-years-old vs 96.7%, 95.9%, and 95.0%, respectively, in the <65-year-old donor group. Multivariate analysis showed the variables associated with patient survival to be donor age at time of transplantation in years (hazard ratio [HR], 1.65; 95% confidence interval [CI], 1.59-1.71; P < .05), time on dialysis in months (HR, 1.22; 95% CI, 1.21-1.23; P = .002). Graft survival rates at 1, 2, and 3 years censored for death with functional graft at was 97.6%, 96.4%, and 94.1%, respectively, for patients transplanted with kidneys from donors older than 65 years vs 97.5%, 96.8%, and 95.2%, respectively, in the <65-year-old donor group. Multivariate analysis, HLA-DR mismatches (HR, 1.23; 95% CI, 1.12-1.55; P = .050), delayed graft function (HR, 1.77; 95% CI, 1.53-2.07; P = .021), and perhaps acute rejection (HR 1.14; 95% CI, 0.82-1.95; P = .093) were the variables associated with graft survival. Conclusion. We concluded that the use of kidneys from donors older than 65 years of age allows us to increase the rate of renal transplantation to approximately 15 to 20 per million population, with good graft and patient survivals provided that the protocol for expanded criteria organs ensured proper macroscopic and microscopic evaluation of the organ for transplantation.en_US
dc.identifier.doi10.1016/j.transproceed.2015.04.015
dc.identifier.endpage1311en_US
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.issue5en_US
dc.identifier.pmid26093706
dc.identifier.startpage1309en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2015.04.015
dc.identifier.urihttps://hdl.handle.net/20.500.12939/587
dc.identifier.volume47en_US
dc.identifier.wosWOS:000357066800017
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorTekin, S.
dc.language.isoen
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedings
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectKidneyen_US
dc.subjectDonoren_US
dc.subjectKidney Transplantationen_US
dc.titleKidney transplantation from elderly donor
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Cerrahi Tıp Bilimleri Bölümü Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu