Formulation, optimization and in vitro evaluation of polymer-coated liposomes encapsulating nebivolol hydrochloride

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dc.contributor.authorSessevmez, Melike
dc.contributor.authorSinani, Genada
dc.contributor.authorÇevikelli, Tilbe
dc.date.accessioned2023-07-13T12:02:12Z
dc.date.available2023-07-13T12:02:12Z
dc.date.issued2023en_US
dc.departmentFakülteler, Eczacılık Teknolojisi Bilimleri Bölümü, Farmasötik Teknoloji Ana Bilim Dalıen_US
dc.description.abstractHypertension, also known as high blood pressure, is a serious medical condition that affects billions of people worldwide. Nebivolol hydrochloride, a & beta;1-adrenergic blocking agent, is used by the oral route in the treatment of hypertension and congestive heart failure. However, its lipophilic nature and poor aqueous solubility restricts its oral bioavailability. To overcome limitations related with conventional oral formulations of the drug, uncoated and polymer-coated liposomes were developed and evaluated. Liposomes loaded with nebivolol hydrochloride were prepared by thin-film hydration method and characterized. The influence of chitosan or pluronic (F127) coating on the liposome properties was evaluated in terms of physicochemical characteristics, stability in simulated gastrointestinal fluids, mucin interaction, in vitro drug release and cytotoxicity studies. It was observed that coating the liposomes with either chitosan or pluronic affected the size, surface charge and encapsulation efficiency of the formulations. The surface morphology studies confirmed the vesicular shape of liposomes. The results obtained indicated that both polymer-coated liposome formulations maintained their stability in simulated gastrointestinal fluids and showed significant in vitro interaction with mucin. Polymer-coated liposome formulations showed much better cumulative release of the drug than uncoated liposomes. No aggregation was observed at the end of four-week storage period and low toxicity in Caco-2 cells was measured. The results demonstrated that polymer coating of liposomes could enhance the in vitro release of nebivolol hydrochloride and interaction with mucin following oral administration and might be attractive alternative nanocarriers to traditional oral formulations.en_US
dc.identifier.citationSessevmez, M., Sinani, G., & Çevikelli, T. (2023). Formulation, optimization and in vitro evaluation of polymer-coated liposomes encapsulating nebivolol hydrochloride. International Journal of Polymeric Materials and Polymeric Biomaterials.en_US
dc.identifier.issn0091-4037
dc.identifier.issn1563-535X
dc.identifier.scopus2-s2.0-85162924406
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/20.500.12939/3560
dc.identifier.wosWOS:001011759800001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorSinani, Genada
dc.language.isoen
dc.relation.ispartofInternational Journal of Polymeric Materials and Polymeric Biomaterials
dc.relation.isversionof10.1080/00914037.2023.2225117en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChitosanen_US
dc.subjectLiposomeen_US
dc.subjectMucin Interactionen_US
dc.subjectOralen_US
dc.subjectPluronicen_US
dc.titleFormulation, optimization and in vitro evaluation of polymer-coated liposomes encapsulating nebivolol hydrochloride
dc.typeArticle

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