Comparison of the effects of two different low-doses of isobaric bupivacaine on intraoperative hemodynamics under spinal anaesthesia during caesarean section: a randomized controlled trial

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dc.contributor.authorDostbil, Ayşenur
dc.contributor.authorAtalay, Canan
dc.contributor.authorİnce, İlker
dc.contributor.authorAksoy, Mehmet
dc.contributor.authorÖzmen, Özgur
dc.contributor.authorKasali, Kamber
dc.contributor.authorYapca, Ömer Erkan
dc.contributor.authorKüçün, Tuğberk
dc.contributor.authorAksoy, Ayşe Nur
dc.contributor.authorŞenocak, Gamze Nur Cimilli
dc.date.accessioned2023-12-21T09:08:43Z
dc.date.available2023-12-21T09:08:43Z
dc.date.issued2023en_US
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: The objective of this study was to conduct a randomized controlled trial in order to examine the hemodynamic impacts of two different doses of intrathecal isobaric bupivacaine (5 mg and 7 mg) when combined with 15 μg fentanyl in the context of patients undergoing caesarean section under combined spinal epidural anesthesia. Methods: Eighty patients with American Society of Anesthesiologists physical status I and II, aged between 16-50 years, who would undergo elective caesarean section under combined spinal epidural anaesthesia were randomly allocated to Group A and Group B (n = 40, for each group). Group A patients received a solution containing 5 mg isobaric bupivacaine + 15 μg fentanyl (1.3 mL), while Group B patients received a solution containing 7 mg isobaric bupivacaine + 15 μg fentanyl (1.7 mL) intrathecally. Incidences of hypotension, intraoperative systolic blood pressure, diastolic blood pressure, heart rate, motor block resolving time, and analgesia duration were recorded. Results: Group A had a substantially lower incidence of hypotension than Group B (p = 0.022). Patients in Group B had significantly lower systolic blood pressure values at the 6th, 8th, 10th, 12th, 14th, 15th, and 30th minutes of the surgery compared to Group A (p = 0.012, p = 0.014, p = 0.005, p = 0.016, p < 0,001, p = 0.002, and p = 0.011; respectively). Both groups had similar diastolic blood pressure and heart rate values during surgery (p > 0.05). The motor block resolving time and analgesia duration were longer in Group B compared to Group A (p < 0.001 for both). Two (5%) patients in Group A and ten (25%) patients in Group B experienced postoperative itching (p = 0.012). Conclusions: We concluded that combining 5 mg isobaric bupivacaine with 15 mcg of fentanyl administered intrathecally provides adequate anaesthesia while maintaining better hemodynamic stability in patients undergoing caesarean section.en_US
dc.identifier.citationDostbil, A., Atalay, C., Ince, I., Aksoy, M., Ozmen, O., Kasali, K., Yapca, O. E., Kucun, T., Aksoy, A. N., Senocak, G. N. C. (2023). Comparison of the effects of two different low-doses of isobaric bupivacaine on intraoperative hemodynamics under spinal anaesthesia during caesarean section: a randomized controlled trial. Clinical and Experimental Obstetrics and Gynecology, 50(11). CEOG5011241en_US
dc.identifier.issn0390-6663
dc.identifier.issue11en_US
dc.identifier.scopus2-s2.0-85179480173
dc.identifier.scopusqualityQ4
dc.identifier.urihttps://hdl.handle.net/20.500.12939/4399
dc.identifier.volume50en_US
dc.identifier.wosWOS:001124027100019
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorİnce, İlker
dc.language.isoen
dc.publisherIMR Press Limiteden_US
dc.relation.ispartofClinical and Experimental Obstetrics and Gynecology
dc.relation.isversionof10.31083/J.CEOG5011241en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCaesarean sectionen_US
dc.subjectHemodynamicsen_US
dc.subjectLow dose bupivacaineen_US
dc.subjectSpinal anaesthesiaen_US
dc.titleComparison of the effects of two different low-doses of isobaric bupivacaine on intraoperative hemodynamics under spinal anaesthesia during caesarean section: a randomized controlled trial
dc.typeArticle

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