Quetiapine improves sensorimotor gating deficit in a sleep deprivation-induced rat model

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dc.contributor.authorÖzcan, Öznur Özge
dc.contributor.authorÇevreli, Burcu
dc.contributor.authorTemizyürek, Arzu
dc.contributor.authorKarahan, Mesut
dc.contributor.authorKonuk, Muhsin
dc.date.accessioned2023-12-29T13:59:06Z
dc.date.available2023-12-29T13:59:06Z
dc.date.issued2023en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri, Fizyoloji Ana Bilim Dalıen_US
dc.description.abstractBackground: Sleep deprivation (SD) impairs pre-stimulus inhibition, but the effect of quetiapine (QET) remains largely unknown. Objective: This study aimed to investigate the behavioral and cognitive effects of QET in both naïve and sleep-deprived rats. Materials and methods: Seven groups (n = 49) of male Wistar Albino rats were used in this study. SD was performed using the modified multiple platform technique in a water tank for 72 h. Our study consists of two experiments investigating the effect of QET on pre-pulse inhibition (PPI) of the acoustic startle reflex. The first experiment tested the effect of short- and long-term administration of QET on PPI response in non-sleeping (NSD) rats. The second experiment used 72 h REM sleep deprivation as a model for SD-induced impairment of the PPI response. Here, we tested the effect of QET on the % PPI of SD rats by short- and long-term intraperitoneal injection at the last 90 min of sleep SD and immediately subsequently tested for PPI. Results: 72 h SD impaired PPI, reduced startle amplitude, and attenuated the PPI% at + 4 dB, + 8 dB, and + 16 dB prepulse intensities. 10 mg/kg short and long-term QET administration completely improved sensorimotor gating deficit, increased startle amplitude, and restored the impaired PPI% at + 4 dB, + 8 dB, and + 16 dB after 72 h SD in rats. Conclusion: Our results showed short- and long-term administration of QET improved sensorimotor gating deficit in 72 h SD. Further research is required for the etiology of insomnia and the dose-related behavioral effects of QET.en_US
dc.identifier.citationÖzcan, Ö. Ö., Çevreli, B., Temizyürek, A., Karahan, M., Konuk, M. (2023). Quetiapine improves sensorimotor gating deficit in a sleep deprivation-induced rat model. Sleep and Biological Rhythms, 22(2), 269-278. 10.1007/s41105-023-00504-xen_US
dc.identifier.issn1446-9235
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85179658575
dc.identifier.scopusqualityQ3
dc.identifier.startpage269en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/4477
dc.identifier.volume22en_US
dc.identifier.volume278en_US
dc.identifier.wosWOS:001122628400001
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorTemizyürek, Arzu
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofSleep and Biological Rhythms
dc.relation.isversionof10.1007/s41105-023-00504-xen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPrepulse inhibitionen_US
dc.subjectPsychosisen_US
dc.subjectQuetiapineen_US
dc.subjectRaten_US
dc.subjectSensorimotor gatingen_US
dc.subjectSleep deprivationen_US
dc.titleQuetiapine improves sensorimotor gating deficit in a sleep deprivation-induced rat model
dc.typeArticle

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