Effects of chemo-therapeutic drugs used in head and neck cancers on submandibular glands of rats
Yükleniyor...
Dosyalar
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Termedia Publishing House Ltd.
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Introduction: Chemo-therapeutic drugs can cause morphological damages to the salivary glands. Objectives: This study aimed to analyze and elucidate 5-fluorouracil (5-FU), cisplatin, methotrexate (MTX), and adriamycin (ADR)-induced morphological changes on submandibular glands (SMGs) of the rats. Material and methods: Forty male Wistar albino rats were divided into five groups, with 8 rats per group. In the control group, 1 ml/kg 0.9% sterile saline solution; in the second group, 100 mg/kg dose of 5-FU; in the third group, 5 mg/kg dose of cisplatin; in the fourth group, 15 mg/kg dose of MTX; in the fifth group, 15 mg/kg dose of ADR were injected once a day for three consecutive days intra-peritoneally. In all groups, SMGs were excised, histopathological analyses were done using a light microscope, and total protein content was analyzed according to Lowry method. Data were examined using analysis of variance (ANOVA), Tukey HSD, Kruskal-Wallis, and Dunn’s tests. Results were evaluated at 95% confidence interval and significance level of p < 0.05. Results: There was a statistically significant decrease in gland weight and total protein content of the 5-FU, ADR, and cisplatin groups compared to that of the control (p < 0.001). However, the decrease in gland weight and total protein content of MTX group was not statistically significant (p > 0.05). Acinus areas of 5-FU, ADR, cisplatin, and MTX groups were lower than that of the control significantly (p < 0.001). Conclusions: According to morphological parameters of our study, the most toxic effects were found to be caused by 5-FU, followed by ADR and cisplatin, while MTX presented the least toxic effects on the rats’ SMGs.
Açıklama
Anahtar Kelimeler
5-FU, Adriamycin, Cisplatin, Methotrexate, Submandibular Gland
Kaynak
Journal of Stomatology
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
75
Sayı
2
Künye
Yurdabakan, Z., Özcan, I., Solakoğlu, S. (2022). Effects of chemo-therapeutic drugs used in head and neck cancers on sub-mandibular glands of rats. Journal of Stomatology, 75(2), 61-71.
