Effects of chemo-therapeutic drugs used in head and neck cancers on submandibular glands of rats

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dc.authorid0000-0002-0591-4464en_US
dc.contributor.authorYurdabakan, Zeliha Zuhal
dc.contributor.authorÖzcan, İlknur
dc.contributor.authorSolakoğlu, Seyhun
dc.date.accessioned2022-08-08T13:22:35Z
dc.date.available2022-08-08T13:22:35Z
dc.date.issued2022en_US
dc.departmentFakülteler, Diş Hekimliği Fakültesi, Ağız, Diş, Çene Radyolojisi Ana Bilim Dalıen_US
dc.description.abstractIntroduction: Chemo-therapeutic drugs can cause morphological damages to the salivary glands. Objectives: This study aimed to analyze and elucidate 5-fluorouracil (5-FU), cisplatin, methotrexate (MTX), and adriamycin (ADR)-induced morphological changes on submandibular glands (SMGs) of the rats. Material and methods: Forty male Wistar albino rats were divided into five groups, with 8 rats per group. In the control group, 1 ml/kg 0.9% sterile saline solution; in the second group, 100 mg/kg dose of 5-FU; in the third group, 5 mg/kg dose of cisplatin; in the fourth group, 15 mg/kg dose of MTX; in the fifth group, 15 mg/kg dose of ADR were injected once a day for three consecutive days intra-peritoneally. In all groups, SMGs were excised, histopathological analyses were done using a light microscope, and total protein content was analyzed according to Lowry method. Data were examined using analysis of variance (ANOVA), Tukey HSD, Kruskal-Wallis, and Dunn’s tests. Results were evaluated at 95% confidence interval and significance level of p < 0.05. Results: There was a statistically significant decrease in gland weight and total protein content of the 5-FU, ADR, and cisplatin groups compared to that of the control (p < 0.001). However, the decrease in gland weight and total protein content of MTX group was not statistically significant (p > 0.05). Acinus areas of 5-FU, ADR, cisplatin, and MTX groups were lower than that of the control significantly (p < 0.001). Conclusions: According to morphological parameters of our study, the most toxic effects were found to be caused by 5-FU, followed by ADR and cisplatin, while MTX presented the least toxic effects on the rats’ SMGs.en_US
dc.identifier.citationYurdabakan, Z., Özcan, I., Solakoğlu, S. (2022). Effects of chemo-therapeutic drugs used in head and neck cancers on sub-mandibular glands of rats. Journal of Stomatology, 75(2), 61-71.en_US
dc.identifier.endpage71en_US
dc.identifier.issn00114553
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85134524702
dc.identifier.scopusqualityQ4
dc.identifier.startpage61en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/2810
dc.identifier.volume75en_US
dc.indekslendigikaynakScopus
dc.institutionauthorYurdabakan, Zeliha Zuhal
dc.language.isoen
dc.publisherTermedia Publishing House Ltd.en_US
dc.relation.ispartofJournal of Stomatology
dc.relation.isversionof10.5114/jos.2022.117327en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject5-FUen_US
dc.subjectAdriamycinen_US
dc.subjectCisplatinen_US
dc.subjectMethotrexateen_US
dc.subjectSubmandibular Glanden_US
dc.titleEffects of chemo-therapeutic drugs used in head and neck cancers on submandibular glands of rats
dc.typeArticle

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