Formulation Optimization on Semi-Solid NLC Dispersions Containing Antioxidant Herbal Oils: A Novel Approach for Cosmeceuticals

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dc.contributor.authorBadıllı, Ulya
dc.contributor.authorÇakır, Kerem
dc.contributor.authorYeğen, Gizem
dc.contributor.authorİnal, Özge
dc.contributor.authorAksu, Buket
dc.date.accessioned2025-08-14T17:00:35Z
dc.date.available2025-08-14T17:00:35Z
dc.date.issued2025
dc.departmentFakülteler, Eczacılık Teknolojisi Bilimleri Bölümü, Farmasötik Teknoloji Ana Bilim Dalı
dc.descriptionCODEN : JAOCA
dc.description.abstractSkin aging prevention is increasingly important in cosmetics. Topical application of antioxidants protects the skin against reactive oxygen species (ROS) generated as a result of continuous exposure to UV radiation. Herbal oils offer significant anti-aging potential due to their antioxidant content. Lipid nanoparticles (i.e., SLN and NLC) have been comprehensively evaluated for dermal drug delivery and cosmetic applications since they offer enhanced skin hydration and improved percutaneous penetration. The latest approach for dermal application is the usage of semi-solid lipid nanoparticle dispersions, which offer unique advantages. Semi-solid SLN/NLC dispersions have a suitable consistency for dermal application and can be prepared by a one-step production method without additional excipients. Furthermore, they preserve the colloidal particle size in spite of their semi-solid consistency. Development of novel cosmeceutical semi-solid NLC dispersions containing valuable herbal oils such as pomegranate seed, argan, grape seed, and coconut oils was aimed at in this study. Formulation optimization was performed using a modeling program based on response surface methodology (RSM). Optimum semi-solid NLC formulation (Opt-NLC) was prepared using Compritol 888ATO and argan oil at amounts of 0.8403 and 0.5457 g, respectively. The particle size of the Opt-NLC formulation was found to be 188.6 ± 3.58 nm, which falls within the targeted size range. PDI was also reduced and a more uniform particle size was obtained by optimization. Rheological and mechanical characterization results revealed that Opt-NLC has suitable properties in terms of product performance and consumer compliance. As a result, formulation optimization of semi-solid NLC dispersions containing antioxidant herbal oils was successfully performed using RSM methodology.
dc.identifier.citationBadilli, U., Cakir, K., Yegen, G., Inal, O., & Aksu, B. (2025). Formulation Optimization on Semi‐Solid NLC Dispersions Containing Antioxidant Herbal Oils: A Novel Approach for Cosmeceuticals. Journal of the American Oil Chemists' Society. 10.1002/aocs.12964
dc.identifier.doi10.1002/aocs.12964
dc.identifier.issn0003-021X
dc.identifier.scopus2-s2.0-105007875413
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://hdl.handle.net/20.500.12939/5876
dc.identifier.wosWOS:001507865500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.institutionauthorYeğen, Gizem
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc
dc.relation.ispartofJAOCS, Journal of the American Oil Chemists' Society
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Öğrenci
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectantioxidant herbal oils
dc.subjectcosmeceutical
dc.subjectformulation optimization
dc.subjectresponse surface methodology (RSM)
dc.subjectsemi-solid NLC dispersion
dc.subjectskin aging
dc.titleFormulation Optimization on Semi-Solid NLC Dispersions Containing Antioxidant Herbal Oils: A Novel Approach for Cosmeceuticals
dc.typeArticle

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