Investigation of antioxidant, antityrosinase, anticollagenase and cytotoxic effects of some Asphodelus species as potential dermocosmetic agent

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dc.contributor.authorBadem, Merve
dc.contributor.authorKanbolat, Şeyda
dc.contributor.authorKanbolat, Şeyda
dc.contributor.authorÇolak, Nevin Ulaş
dc.contributor.authorŞener, Sıla Özlem
dc.contributor.authorAli, Yasemin Altun
dc.contributor.authorErdemir, Burcu
dc.contributor.authorSarı, Sena
dc.contributor.authorŞenel, Hatice
dc.contributor.authorArıkan, Fatma
dc.contributor.authorNath, Ebru Özdemir
dc.date.accessioned2024-09-18T13:07:48Z
dc.date.available2024-09-18T13:07:48Z
dc.date.issued2024en_US
dc.departmentFakülteler, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Botanik Ana Bilim Dalıen_US
dc.description.abstractVarious studies have reported the antimicrobial, antifungal, and antioxidant effects of Asphodelus species. These species are used in the treatment of various skin-related issues such as acne, abscesses, psoriasis, burns, alopecia, wound healing, and eczema in folk medicine. The purpose of the present study is to determine the antioxidant, antityrosinase, anticollagenase and cytotoxic effects of Asphodelus aestivus and Asphodelus fistulosus as potential dermocosmetic agent, as well as the phenolic substance profiles of the species by Reversed phase high performance liquid chromatography (RP-HPLC). Antioxidant capacity of the species was determined by total phenolic and flavonoid content determination, cupric ion reducing power (CUPRAC), ferric ion reducing power (FRAP) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity assays. Enzyme inhibition studies were conducted spectrophotometrically. The cytotoxic activity was analyzed by the 3-(4, 5-dimethylthiazolyl-2)-2, 5diphenyltetrazolium bromide (MTT) assay. As a result, it was determined that the methanolic extracts obtained from the species showed strong antioxidant activity. Based on the CUPRAC and DPPH results, A. aestivus was found to be more effective while according to the FRAP results, A. fistulosus exhibited greater effectiveness. A. fistulosus was discovered to be abundant in phenolic substances, while A. aestivus was found to be richer in flavonoids. It has also been observed that the methanolic extracts have a high inhibitory effect on collagenase and tyrosinase enzymes. It is believed that the species can be used as a potential resource in the treatment of skin aging and hyperpigmentation problems in the dermocosmetic industry. It is thought that the data obtained in the study will lead to further studies.en_US
dc.identifier.citationBadem, M., Kanbolat, Ş., Çolak, N. U., Şener, S. O., Ali, Y. A., Erdemir, B., Sarı, S., Şenel, H., Arıkan, F, Nath, E. O. (2024). Investigation of antioxidant, antityrosinase, anticollagenase and cytotoxic effects of some Asphodelus species as potential dermocosmetic agent. Food Bioscience, 61. 10.1016/j.fbio.2024.104891en_US
dc.identifier.issn2212-4292
dc.identifier.issn2212-4306
dc.identifier.scopus2-s2.0-85201201247
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/20.500.12939/4920
dc.identifier.volume61en_US
dc.identifier.wosWOS:001297872700001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.relation.ispartofFood Bioscience
dc.relation.isversionof10.1016/j.fbio.2024.104891en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.relation.tubitakTurkish Scientific and Technical Research Council
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAsphodelusen_US
dc.subjectCollagenaseen_US
dc.subjectTyrosinaseen_US
dc.subjectDermocosmeticsen_US
dc.subjectOxidative stressen_US
dc.subjectHPLCen_US
dc.titleInvestigation of antioxidant, antityrosinase, anticollagenase and cytotoxic effects of some Asphodelus species as potential dermocosmetic agent
dc.typeArticle

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