Quality by design (QbD) approach and application of preformulation studies for a poorly water soluble model drug, Nimesulid

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dc.contributor.authorÖzalp, Yıldız
dc.contributor.authorKhamis, Hala
dc.contributor.authorJiwa, Nailla
dc.contributor.authorMesut, Burcu
dc.contributor.authorAksu, Buket
dc.date.accessioned2023-03-03T08:17:41Z
dc.date.available2023-03-03T08:17:41Z
dc.date.issued2023en_US
dc.departmentFakülteler, Eczacılık Teknolojisi Bilimleri Bölümü, Farmasötik Teknoloji Ana Bilim Dalıen_US
dc.description.abstractFormulating poorly water-soluble medications is one of the most crucial challenges encountered in the pharmaceutical industry. Due to this obstacle, the model drug chosen for this research was Nimesulide. The primary goal of this research was to obtain information on the drug's physical and chemical properties, either alone or in combination with excipients, in order design a formulation and create a stable and bioavailable dosage form. Formulations were designed using Flowlac (R) 100 and Avicel (R) 102 as fillers, Kollidon (R) 30 as a binder, Magnesium stearate as a lubricant, and variable concentrations of Kollidon (R) CL and Primojel as superdisintegrants. The tableting process was conducted using a compaction simulator. The Quality by Design (QbD) approach allows formulators to enhance product development with built-in product quality. In this study, to understand the relationship between excipients and compaction force differences on tablet properties, the QbD approach was applied by using a compaction simulator.en_US
dc.identifier.citationÖzalp, Y., Khamis, H., Jiwa, N., Mesut, B., Aksu, N. (2023). Quality by design (QbD) approach and application of preformulation studies for a poorly water soluble model drug, Nimesulid. Acta Farmaceutica Bonaerense, 42(1), 142-149.en_US
dc.identifier.endpage149en_US
dc.identifier.issn0326-2383
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85162157683
dc.identifier.scopusqualityN/A
dc.identifier.startpage142en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/3435
dc.identifier.volume42en_US
dc.identifier.wosWOS:000920231700021
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorAksu, Buket
dc.language.isoen
dc.relation.ispartofActa Farmaceutica Bonaerense
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCompaction Simulator Nimesulideen_US
dc.subjectQuality by Designen_US
dc.titleQuality by design (QbD) approach and application of preformulation studies for a poorly water soluble model drug, Nimesulid
dc.typeArticle

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