Chemical composition of different parts of the vitex agnus-castus l. essential oils and their in-vitro cytotoxic activities

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dc.authorid0000-0002-0250-9084en_US
dc.contributor.authorİnal, Ebrar
dc.contributor.authorNath, Ebru Ozdemir
dc.contributor.authorAbudayyak, Mahmoud
dc.contributor.authorUlusoy, Şeyma
dc.contributor.authorİnan, Hatice Akbal
dc.contributor.authorÇicek, Mahmut
dc.contributor.authorKartal, Murat
dc.date.accessioned2023-09-06T08:49:43Z
dc.date.available2023-09-06T08:49:43Z
dc.date.issued2023en_US
dc.departmentFakülteler, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Botanik Ana Bilim Dalıen_US
dc.description.abstractThe essential oil (EO) compositions and chemotypes of the important ethnomedicinal plant Vitex agnus-castus L. flowers, leaves, and fruits collected from Turkiye (Balikesir and Istanbul) were identified in the present study. Different parts of the V. agnus-castus EO's in-vitro cytotoxic effects on the MCF-7 (human breast adenocarcinoma) and A549 (human lung carcinoma) human-origin cell lines were anaylzed in the current study. The composition of hydrodistiled EOs extracted from flowers, leaves, and fruits of V. agnus-castus were analyzed by GC-FID/MS. Monoterpene hydrocarbons and oxygenated monoterpene compounds were detected as the predominant component class of the V. agnus-castus. EOs extracted from Balikesir region were defined as the "apinene-1,8-cineole" chemotype, while EOs extracted from Istanbul region were defined as the "sabinene-1,8-cineole" chemotype. Sesquiterpene hydrocarbons constituted more than 20% of the compounds in the EOs extracted from the flowers. To the best of our knowledge, this study is the first to analyze the in-vitro cytotoxic effects of flowers. This study is also the first to show the in-vitro cytotoxic effects of fruit, the most commonly used part of the plant, EO on the MCF-7 cell line. Balikesir region's EOs were observed as more potent-especially the purple flower's IC50 is about 4.68 mu g/mL on the MCF7 cell line- than Istanbul regions, which might be attributed to the higher amount of a-pinene, caryophyllene, and limonene content. Our results indicated that the V. agnus-castus EOs, which contain a-pinene, 1,8-cineole, caryophyllene, and limonene as major components, showed relatively high cytotoxic effects compared to the control groups on the MCF7 and A549 cell lines.en_US
dc.identifier.citationİnal, E., Nath, E. Ö., Abudayyak, M., Ulusoy, Ş., İnan, H. A., Çiçek, M., & Kartal, M. (2023). Chemical composition of different parts of the vitex agnus-castus l. essential oils and their in-vitro cytotoxic activities. Records of Natural Products.en_US
dc.identifier.issn1307-6167
dc.identifier.scopus2-s2.0-85171357676
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://hdl.handle.net/20.500.12939/3808
dc.identifier.wosWOS:001033834400001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorNath, Ebru Ozdemir
dc.language.isoen
dc.relation.ispartofRecords of Natural Products
dc.relation.isversionof10.25135/rnp.404.2304.2761en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectVitex agnus-castus L.en_US
dc.subjectChasteberryen_US
dc.subjectEssential Oilen_US
dc.subjectCanceren_US
dc.subjectCytotoxicityen_US
dc.titleChemical composition of different parts of the vitex agnus-castus l. essential oils and their in-vitro cytotoxic activities
dc.typeArticle

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