Evaluation of Subclinical Left Ventricular Dysfunction in HIV Patients Receiving Abacavir, Dolutegravir, and Lamivudine Therapy with Novel Tissue Doppler Imaging Techniques

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dc.authorid0000-0003-4548-9543
dc.authorid0000-0001-7859-4804
dc.authorid0000-0002-1761-8304
dc.authorid0000-0002-7023-6639
dc.authorid0000-0001-6905-0776
dc.contributor.authorOkşen, Doğaç
dc.contributor.authorAslan, Muzaffer
dc.contributor.authorSerin, Ebru
dc.contributor.authorGeçit, Muhammed Heja
dc.contributor.authorYavuz, Yunus Emre
dc.contributor.authorYerlikaya Zerdali, Esra
dc.contributor.authorOktay, Veysel
dc.date.accessioned2025-06-11T13:25:35Z
dc.date.available2025-06-11T13:25:35Z
dc.date.issued2025
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.description.abstractBackground/Objectives: Highly active antiretroviral therapy (HAART) effectively suppresses viral load and aids immunological recovery in HIV patients, but may still lead to subclinical myocardial dysfunction. This study assesses left and right ventricular functions in patients on HAART containing abacavir, dolutegravir, and lamivudine using Tissue Doppler Imaging (TDI). Methods: This observational cross-sectional study involved 118 HIV-positive adults on HAART and 80 age- and gender-matched healthy controls. Comprehensive echocardiographic assessments, including TDI, were conducted to evaluate myocardial performance index (MPI) and isovolumic acceleration (IVA). Results: Conventional echocardiographic parameters showed no significant differences; however, TDI indicated significant impairments in ventricular functions in the HAART group, with increased MPI and decreased IVA (p < 0.001). Pulmonary artery pressures were also higher in the HIV group (p = 0.012). There was a strong positive correlation between MPI and HAART duration (r = 0.675, p = 0.002), and a negative correlation with CD4 count (r = −0.545, p = 0.006). Conclusions: TDI reveals significant subclinical ventricular dysfunction in HIV patients on HAART, correlating with therapy duration and immune status. These findings underscore the utility of TDI in detecting myocardial deterioration before clinical symptoms appear.
dc.identifier.citationOksen, D., Aslan, M., Serin, E., Gecit, M. H., Yavuz, Y. E., Zerdali, E. Y., & Oktay, V. (2025). Evaluation of Subclinical Left Ventricular Dysfunction in HIV Patients Receiving Abacavir, Dolutegravir, and Lamivudine Therapy with Novel Tissue Doppler Imaging Techniques. Journal of Clinical Medicine, 14(5), 1534.
dc.identifier.doi10.3390/jcm14051534
dc.identifier.issn2077-0383
dc.identifier.issue5
dc.identifier.pmid40095518
dc.identifier.scopus2-s2.0-86000596735
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/20.500.12939/5771
dc.identifier.volume14
dc.indekslendigikaynakPubMed
dc.institutionauthorOkşen, Doğaç
dc.institutionauthorid0000-0003-4548-9543
dc.language.isoen
dc.publisherMDPI
dc.relation.ispartofJournal of Clinical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjecthighly active antiretroviral therapy
dc.subjecthuman immunodeficiency virus
dc.subjectisovolumic acceleration
dc.subjectmyocardial performance index
dc.subjectsubclinical ventricular dysfunction
dc.subjecttissue Doppler imaging
dc.titleEvaluation of Subclinical Left Ventricular Dysfunction in HIV Patients Receiving Abacavir, Dolutegravir, and Lamivudine Therapy with Novel Tissue Doppler Imaging Techniques
dc.typeArticle

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