Nidogen-2: A new biomarker in colon cancer patients

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dc.authoridKemik, Ozgur/0000-0002-4612-1428
dc.contributor.authorKiziltan, Remzi
dc.contributor.authorCikman, Oztekin
dc.contributor.authorAlgul, Sermin
dc.contributor.authorAydin, Mehmet Akif
dc.contributor.authorKemik, Ozgur
dc.date.accessioned2025-02-06T17:58:26Z
dc.date.available2025-02-06T17:58:26Z
dc.date.issued2022
dc.departmentAltınbaş Üniversitesien_US
dc.description.abstractAIM: In the present study, we followed Nidogen-2 levels and clinicopathological parameters of patients with colon cancer. MATERIAL AND METHODS: Eighty-eight patients (F/M, 43/45; Mean age +/- SD, 57.86 +/- 1.78 years) were included. The results of serum Nidogen-2 levels were shown with respect to stage, gender, age, and metastasis. Nidogen-2 levels in the sera of colon cancer patients and healthy donors were analyzed with ELISA. RESULTS: The expression levels were significantly higher in patients (1010.8 +/- 184.36 pg/mL) than in healthy subjects (51.85 +/- 1.44 pg/mL; p<0.001). Moreover, the Nidogen-2 expression significantly increased in the clinical stages of colon cancer (p<0.01). The Nidogen-2 levels did not vary by patient age or gender. DISCUSSION: Under normal conditions, Nidogen-2 is a basal membrane protein. Nidogen-2 is primarily expressed in the extracellular matrix. Nidogen-2 has been defined as a major means to analyze the molecular pathways involved in cancer development and progression. Besides its important functions, it has been hypothesized that secreted Nidogen-2 may be a diagnostic biomarker for cancer detection. CONLUSION: These findings suggest that increased expression of Nidogen-2 may have great pathological importance in the development of colon cancer and may also show a diagnostic value for colon cancer.en_US
dc.identifier.endpage92en_US
dc.identifier.issn0003-469X
dc.identifier.issn2239-253X
dc.identifier.issue1en_US
dc.identifier.pmid34593672
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage88en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/5257
dc.identifier.volume93en_US
dc.identifier.wosWOS:000886951900012
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherEdizioni Luigi Pozzien_US
dc.relation.ispartofAnnali Italiani Di Chirurgiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250206
dc.subjectAngiogenesisen_US
dc.subjectMetastasisen_US
dc.subjectNidogen-2en_US
dc.titleNidogen-2: A new biomarker in colon cancer patientsen_US
dc.typeArticleen_US

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