Optimization of Morris Water Maze protocols : effects of water temperature and hypothermia on spatial learning and memory in aged female rats

Basit Öğe Kaydı
dc.contributor.authorOran, Duygu Sultan
dc.contributor.authorTemel, Zeynep
dc.contributor.authorBaşer, İbrahim Gökşin
dc.contributor.authorTemizyürek, Arzu
dc.contributor.authorSelcan, Ayşin
dc.date.accessioned2025-01-13T12:54:04Z
dc.date.available2025-01-13T12:54:04Z
dc.date.issued2024en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri, Fizyoloji Ana Bilim Dalıen_US
dc.description.abstractIntroduction: Aging is a highly complex process driven by a multitude of factors. The use of humans in aging research is complicated by many factors (ethical issues; environmental and social factors; long natural life span). Therefore, rats are common models for the study of aging and age-related diseases. The Morris water maze test is one of the most common cognitive tests in studies investigating age-related learning and memory. However, standardized protocols are lacking, which could influence results. This study investigated the effects of water temperature and inter-trial interval on physiological parameters, hippocampus-dependent learning, and memory in aged female rats performing the Morris Water Maze. Materials and Methods: Thirty-two female Wistar Hannover rats, aged over 18 months, were divided into four groups based on water temperature (20 °C or 24 °C) and inter-trial interval (30 seconds or 13 minutes). Results: Rats exposed to 24 °C demonstrated better spatial learning and memory retention than those at 20 °C. The interaction between inter-trial interval and water temperature significantly affected memory, with higher temperatures improving memory, especially with shorter intervals. Inter-trial interval alone did not significantly affect learning, but longer durations were associated with more stable body temperatures. Neither water temperature nor inter-trial interval significantly influenced body weight. Conclusion: These findings emphasize the need to standardize environmental conditions in Morris water maze protocols to enhance research validity and reliability. Optimizing these protocols is crucial to upholding ethical standards and ensuring animal welfare, advancing more effective and scientifically sound practices in gerontological research, and fostering a better understanding of aging processes.en_US
dc.identifier.citationOran, D. S., Temel, Z., Başer, İ. G., Temizyürek, A., Selcan, A. (2024). Optimization of Morris Water Maze protocols : effects of water temperature and hypothermia on spatial learning and memory in aged female rats. Turk Geriatri Dergisi, 27(4), 398-408. 10.29400/tjgeri.2024.413en_US
dc.identifier.endpage408en_US
dc.identifier.issn1304-2947
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85213573019
dc.identifier.scopusqualityQ4
dc.identifier.startpage398en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/5142
dc.identifier.volume27en_US
dc.identifier.wosWOS:001383401400008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorTemizyürek, Arzu
dc.language.isoen
dc.publisherTurkish Geriatrics Societyen_US
dc.relation.ispartofTurk Geriatri Dergisi
dc.relation.isversionof10.29400/tjgeri.2024.413en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAgingen_US
dc.subjectAnimal Welfareen_US
dc.subjectBody Temperatureen_US
dc.subjectMemory and Learning Testen_US
dc.subjectMorris Water Maze Testen_US
dc.subjectSpatial Memoryen_US
dc.titleOptimization of Morris Water Maze protocols : effects of water temperature and hypothermia on spatial learning and memory in aged female rats
dc.typeArticle

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