Chronic kidney disease and neurological disorders: are uraemic toxins the missing piece of the puzzle?

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dc.contributor.authorPepin, Marion
dc.contributor.authorFranssen, Casper F.M
dc.contributor.authorViggiano, Davide
dc.contributor.authorCarriazo, Sol
dc.contributor.authorGansevoort, Ron T.
dc.contributor.authorGesualdo, Loreto
dc.contributor.authorMalyszko, Jolanta
dc.contributor.authorMayer, Christopher
dc.contributor.authorNitsch, Dorothea
dc.contributor.authorOrtiz, Alberto
dc.contributor.authorPesic, Vesna
dc.contributor.authorWiecek, Andrzej
dc.contributor.authorMassy, Ziad A.
dc.contributor.author(Cognitive Decline in Nephro-Neurology European Cooperative Target
dc.date.accessioned2022-03-03T06:55:54Z
dc.date.available2022-03-03T06:55:54Z
dc.date.issued2021en_US
dc.departmentFakülteler, Eczacılık Meslek Bilimleri Bölümü, Farmakoloji Ana Bilim Dalıen_US
dc.description.abstractChronic kidney disease (CKD) perturbs the crosstalk with others organs, with the interaction between the kidneys and the heart having been studied most intensively. However, a growing body of data indicates that there is an association between kidney dysfunction and disorders of the central nervous system. In epidemiological studies, CKD is associated with a high prevalence of neurological complications, such as cerebrovascular disorders, movement disorders, cognitive impairment and depression. Along with traditional cardiovascular risk factors (such as diabetes, inflammation, hypertension and dyslipidaemia), non-traditional risk factors related to kidney damage (such as uraemic toxins) may predispose patients with CKD to neurological disorders. There is increasing evidence to show that uraemic toxins, for example indoxyl sulphate, have a neurotoxic effect. A better understanding of factors responsible for the elevated prevalence of neurological disorders among patients with CKD might facilitate the development of novel treatments. Here, we review (i) the potential clinical impact of CKD on cerebrovascular and neurological complications, (ii) the mechanisms underlying the uraemic toxins’ putative action (based on pre-clinical and clinical research) and (iii) the potential impact of these findings on patient care.en_US
dc.identifier.citationLiabeuf, S., Pepin, M., Franssen, C. F., Viggiano, D., Carriazo, S., Gansevoort, R. T., ... & Massy, Z. A. (2022). Chronic kidney disease and neurological disorders: are uraemic toxins the missing piece of the puzzle?. Nephrology Dialysis Transplantation, 37(2), 33-44.en_US
dc.identifier.endpage44en_US
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85123025309
dc.identifier.scopusqualityN/A
dc.identifier.startpage33en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/2256
dc.identifier.volume37en_US
dc.identifier.wosWOS:000740945100005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorHafez, Gaye
dc.language.isoen
dc.publisherNephrol Dial Transplanten_US
dc.relation.ispartofNephrol Dial Transplant
dc.relation.isversionof10.1093/ndt/gfab223en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCardiovascularen_US
dc.subjectCKDen_US
dc.subjectIndoxyl Sulphateen_US
dc.subjectStrokeen_US
dc.subjectUraemic Toxinsen_US
dc.titleChronic kidney disease and neurological disorders: are uraemic toxins the missing piece of the puzzle?
dc.typeArticle

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