Investigation of neurosphere activity of injectable 3D graphene bioink biomaterial

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dc.authorid0000-0002-3555-4850en_US
dc.contributor.authorYıldız, Aslı Pınar Zorba
dc.contributor.authorYavuz, Burçak
dc.contributor.authorAbamor, Emrah Şefik
dc.contributor.authorDarıcı, Hakan
dc.contributor.authorAllahverdiyev, Adil
dc.date.accessioned2024-07-18T11:32:36Z
dc.date.available2024-07-18T11:32:36Z
dc.date.issued2024en_US
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Görüntüleme Teknikleri Programıen_US
dc.descriptionFunding provided by Yıldız Technical University with grant number TSA-2021-4713
dc.description.abstractPurposeThe aim of this study includes the comparative examination of neurosphere formation by WJ-derived mesenchymal stem cells in both 2D media and 3D injectable graphene and graphene-free bioink systems in terms of both immunostaining and gene expression levels.MethodsFor this purpose, hydrogel bioinks were first created and the wj-MKH spheroidal structure was formed on 3D-B (without graphene) and 3D-G (containing graphene). Then, following the differentiation procedure, neurosphere transformations were identified by both immunostaining (b-III Tubulin and Sox2), and Tubulin 3, Sox2, and Nestin markers were examined at the gene expression level with Real-Time PCR, and the results were compared with the 2D environment.ResultsAccording to the results obtained, neurosphere formation occurred more in the 3D environment compared to the 2D environment, obtained both by immunostaining and gene expression levels. It was also observed that differentiation formed neuron-like structures, especially in the 3D-G group containing graphene.ConclusionAs a result, it has been observed that the use of graphene with a non-toxic concentration in the hydrogel injectable system provides better differentiation of stem cells, especially those that will form the cell leg of the biomaterial.Lay SummaryTherefore, the use of graphene-containing hydrogels in injectable systems in nerve damage may increase the effectiveness on nerve regeneration.en_US
dc.identifier.citationYıldız, A. P. Z., Yavuz, B., Abamor, E. S., Darıcı, H., Allahverdiyev, A. (2024). Investigation of neurosphere activity of injectable 3D graphene bioink biomaterial. Regenerative Engineering and Translational Medicine. 10.1007/s40883-024-00336-2en_US
dc.identifier.issn2364-4133
dc.identifier.issn2364-4141
dc.identifier.scopus2-s2.0-85186625835
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://hdl.handle.net/20.500.12939/4757
dc.identifier.wosWOS:001261422000003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorYavuz, Burçak
dc.language.isoen
dc.relation.ispartofRegenerative Engineering and Translational Medicine
dc.relation.isversionof10.1007/s40883-024-00336-2en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGrapheneen_US
dc.subjectBioinken_US
dc.subject3Den_US
dc.subjectNeuroengineeringen_US
dc.titleInvestigation of neurosphere activity of injectable 3D graphene bioink biomaterial
dc.typeArticle

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