Efficacy of metabolically supported chemotherapy combined with ketogenic diet, hyperthermia, and hyperbaric oxygen therapy for stage IV triple-negative breast cancer

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dc.contributor.authorİyikesici, Mehmet Salih
dc.contributor.authorSlocum, Abdul Kadir
dc.contributor.authorSlocum, Ayshe
dc.contributor.authorBerkarda, Ferhan Bulent
dc.contributor.authorKalamian, Miriam
dc.contributor.authorSeyfried, Thomas N.
dc.date.accessioned2021-05-15T12:43:07Z
dc.date.available2021-05-15T12:43:07Z
dc.date.issued2017
dc.departmentTıp Fakültesi, Onkoloji Anabilim Dalıen_US
dc.descriptionSlocum, Ayshe/0000-0002-1612-6076; Seyfried, Thomas/0000-0003-1491-3989
dc.description.abstractTriple-negative breast cancer (TNBC) is more aggressive and metastatic than other breast cancer types. Cytotoxic chemotherapy is presently the predominant systemic therapy for TNBC patients. This case report highlights the influence of metabolically supported chemotherapy (MSCT), ketogenic diet (KD), hyperthermia (HT), and hyperbaric oxygen therapy (HBOT) in an overweight 29-year-old woman with stage IV (T4N3M1) triple-negative invasive ductal carcinoma of the breast. The patient presented with an observable mass in her left breast detected during a physical examination in December 2015. Magnetic resonance imaging revealed a Breast Imaging Reporting and Data System Category 5 tumor and multiple lymphadenomegaly in the left axilla. A Tru-Cut biopsy led to the diagnosis of a triple-negative nuclear grade 2 invasive ductal carcinoma. The patient was admitted to ChemoThermia Oncology Center, Istanbul, Turkey in October 2016, and a whole body (18F)-fluorodeoxyglucose (FDG)-positron emission tomography-computed tomography (PET-CT) scan revealed a 77 mm x 55 mm primary tumor in her left breast, multiple left pectoral and axillary lymph nodes, multiple widespread liver masses, and an upper left nodular abdominal lesion. The patient received a treatment protocol consisting of MSCT, KD, HT, and HBOT. A follow-up whole body 18F-FDG PET-CT scan in February 2017 showed a complete therapeutic response with no evidence of abnormal FDG uptake. The patient continued to receive this treatment protocol and in April 2017 underwent a mastectomy, which revealed a complete pathological response consistent with the response indicated by her PET-CT imaging. This single case study presents evidence of a complete clinical, radiological, and pathological response following a six-month treatment period using a combination of MSCT and a novel metabolic therapy in a patient with stage IV TNBC.en_US
dc.description.sponsorshipSingle Cure Foundationen_US
dc.description.sponsorshipWe thank the Single Cause, Single Cure Foundation for their support.en_US
dc.identifier.citationİyikesici, M. S., Slocum, A. K., Slocum, A., Berkarda, F. B., Kalamian, M., Seyfried, T. N. (2017). Efficacy of metabolically supported chemotherapy combined with ketogenic diet, hyperthermia, and hyperbaric oxygen therapy for stage IV triple-negative breast cancer. Cureus, 9(7). https://doi.org/ 10.7759/cureus.1445
dc.identifier.doi10.7759/cureus.1445
dc.identifier.issn2168-8184
dc.identifier.issue7en_US
dc.identifier.pmid28924531
dc.identifier.urihttps://doi.org/10.7759/cureus.1445
dc.identifier.urihttps://hdl.handle.net/20.500.12939/1009
dc.identifier.volume9en_US
dc.identifier.wosWOS:000453623000031
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorİyikesici, Mehmet Salih
dc.language.isoen
dc.publisherCureus Incen_US
dc.relation.ispartofCureus
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMetabolically Supported Chemotherapyen_US
dc.subjectKetogenic Dieten_US
dc.subjectHyperthermiaen_US
dc.subjectHyperbaric Oxygen Therapyen_US
dc.subjectPathological Complete Responseen_US
dc.subjectTriple Negative Breast Canceren_US
dc.titleEfficacy of metabolically supported chemotherapy combined with ketogenic diet, hyperthermia, and hyperbaric oxygen therapy for stage IV triple-negative breast cancer
dc.typeArticle

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