Determination of antioxidant activity of Salvia sclarea L. and its inhibitory effects on acetylcholinesterase and monoamine oxidase A

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dc.authorid0000-0002-6595-6850en_US
dc.authorid0000-0002-0250-9084en_US
dc.contributor.authorYücel, Yasemin Yücel
dc.contributor.authorNath, Ebru Özdemir
dc.date.accessioned2023-09-19T09:45:22Z
dc.date.available2023-09-19T09:45:22Z
dc.date.issued2023en_US
dc.departmentFakülteler, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalıen_US
dc.description.abstractOver the past two to three decades, there has been a significant increase in research focused on the treatment of neurodegenerative disorders. In this study, our aim was to determine some biological activities of the ethanolic and methanolic extracts of Salvia sclarea L. The extracts were first assessed for their capacity to scavenge DPPH radicals, then their total phenolic content (TPC) were determined. Afterward, the extracts were evaluated for their effects on acetylcholinesterase (AChE) and monoamine oxidase-A (MAO-A). These two enzymes play a crucial role in the treatment of neurodegenerative disorders. It has been found that, the DPPH activity of the methanolic extract was higher than that of ethanolic extracts; while TPC was higher for the ethanolic extract. For AChE, the IC50 values for ethanolic extract and methanolic extract were 0,27±0,005 mg/mL and 1,19±0,037 mg/mL, respectively. And for MAO-A, the IC50 values for ethanolic extract and methanolic extract were 6,53±0,72 mg/ mL and 3,03±0,05 mg/mL, respectively. As the result of this study, the antioxidant property of Salvia sclarea was determined, and it was observed that this property changed in accordance with the total phenolic content of the plant. It has been shown that the extracts have inhibitory effects on both enzymes. This means, the obtained data are promising for further drug development studies.en_US
dc.identifier.citationYücel, Y. Y., & Özdemir, E. (2023). Determination of antioxidant activity of Salvia sclarea L. and its inhibitory effects on acetylcholinesterase and monoamine oxidase A. Fabad Journal of Pharmaceutical Sciences, 48(2), 255-264.en_US
dc.identifier.endpage264en_US
dc.identifier.issn1300-4182
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85169565118
dc.identifier.scopusqualityQ4
dc.identifier.startpage255en_US
dc.identifier.trdizinid1192790
dc.identifier.urihttps://hdl.handle.net/20.500.12939/4046
dc.identifier.volume48en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorYücel, Yasemin Yücel
dc.institutionauthorNath, Ebru Özdemir
dc.language.isoen
dc.publisherSociety of Pharmaceutical Sciences of Ankara (FABAD)en_US
dc.relation.ispartofFabad Journal of Pharmaceutical Sciences
dc.relation.isversionof10.55262/fabadeczacilik.1293118en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectDPPHen_US
dc.subjectMonoamine Oxidase-Aen_US
dc.subjectNeurodegenerative Disordersen_US
dc.subjectSalvia sclarea L.en_US
dc.subjectTotal Phenolic Contenten_US
dc.titleDetermination of antioxidant activity of Salvia sclarea L. and its inhibitory effects on acetylcholinesterase and monoamine oxidase A
dc.title.alternativeSalvia sclarea L.’nin antioksidan aktivitesi ile asetilkolinesteraz ve monoamin oksidaz-A üzerindeki inhibitör etkilerinin belirlenmesi
dc.typeArticle

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