Impact of endometrioma resection on eutopic endometrium metabolite contents: Noninvasive evaluation of endometrium receptivity

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dc.contributor.authorErşahin, Aynur
dc.contributor.authorÇelik, Önder
dc.contributor.authorAcet, Mustafa
dc.contributor.authorErşahin, Süphan
dc.contributor.authorAcet, Tuba
dc.contributor.authorBozkurt, Duygu Kara
dc.contributor.authorİlhan, Selçuk
dc.date.accessioned2021-05-15T12:36:39Z
dc.date.available2021-05-15T12:36:39Z
dc.date.issued2017
dc.departmentTıp Fakültesien_US
dc.description.abstractThe aim of this study was to determine whether endometrioma resection alters most commonly defined endometrial metabolites, lactate (Lac), N-acetylaspartate (NAA), creatine 1 (Cr1), creatine 2 (Cr2), and choline (Cho) during the window of implantation. Twenty patients with uni- or bilateral endometrioma and 7 patients having nonendometriotic benign ovarian cyst were included. Midluteal phase magnetic resonance spectroscopy analysis of eutopic endometrium was performed before surgery. Second spectrum of endometrium was obtained 3 to 5 months after laparoscopic endometrioma resection. Pre- and postoperative endometrial peaks of Lac, NAA, Cr, and Cho were measured in units and denominated in parts per million (ppm). Compared to preoperative peak values, significantly decreased NAA, Lac, and Cr1 signals were noted in patients undergoing endometrioma surgery. Nearly 5-fold decline in the NAA signal occurred after endometrioma surgery (1.94 +/- 3.24 vs 0.37 +/- 0.55). Likewise, 2.5-fold decline in Lac signals was noted after endometrioma resection (2.81 +/- 2.64 vs 1.06 +/- 1.88). Both uni- and bilateral endometrioma affected endometrium signals the same. The peak intensity of Cho, Cr1, Cr2, NAA, and Lac did not alter significantly after nonendometriotic cyst surgery. Endometrioma surgery straightens endometrial NAA, Lac, and Cr1 peaks, suggesting improvement in endometrial receptivity.en_US
dc.identifier.doi10.1177/1933719116670039
dc.identifier.endpage795en_US
dc.identifier.issn1933-7191
dc.identifier.issn1933-7205
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85018741259
dc.identifier.scopusqualityQ1
dc.identifier.startpage790en_US
dc.identifier.urihttps://doi.org/10.1177/1933719116670039
dc.identifier.urihttps://hdl.handle.net/20.500.12939/363
dc.identifier.volume24en_US
dc.identifier.wosWOS:000400087600017
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorErşahin, Süphan
dc.language.isoen
dc.publisherSage Publications Incen_US
dc.relation.ispartofReproductive Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSpectroscopyen_US
dc.subjectEndometriomaen_US
dc.subjectEutopic Endometriumen_US
dc.subjectLaparoscopyen_US
dc.titleImpact of endometrioma resection on eutopic endometrium metabolite contents: Noninvasive evaluation of endometrium receptivity
dc.typeArticle

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