Preparation and characterization of graphene-based 3D biohybrid hydrogel bioink for peripheral neuroengineering

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dc.contributor.authorZorba Yıldız, Aslı Pınar
dc.contributor.authorDarıcı, Hakan
dc.contributor.authorYavuz, Burçak
dc.contributor.authorAbamor, Emrah Şefik
dc.contributor.authorÖzdemir, Ceren
dc.contributor.authorYasin, Müge Elif
dc.contributor.authorBağırova, Melahat
dc.contributor.authorAllahverdiyev, Adil
dc.contributor.authorKaraöz, Erdal
dc.date.accessioned2022-06-20T08:18:05Z
dc.date.available2022-06-20T08:18:05Z
dc.date.issued2022en_US
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Radyoterapi Programıen_US
dc.description.abstractPeripheral neuropathies can occur as a result of axonal damage, and occasionally due to demyelinating diseases. Peripheral nerve damage is a global problem that occurs in 1.5%-5% of emergency patients and may lead to significant job losses. Today, tissue engineering-based approaches, consisting of scaffolds, appropriate cell lines, and biosignals, have become more applicable with the development of three-dimensional (3D) bioprinting technologies. The combination of various hydrogel biomaterials with stem cells, exosomes, or bio-signaling molecules is frequently studied to overcome the existing problems in peripheral nerve regeneration. Accordingly, the production of injectable systems, such as hydrogels, or implantable conduit structures formed by various bioprinting methods has gained importance in peripheral neuro-engineering. Under normal conditions, stem cells are the regenerative cells of the body, and their number and functions do not decrease with time to protect their populations; these are not specialized cells but can differentiate upon appropriate stimulation in response to injury. The stem cell system is under the influence of its microenvironment, called the stem cell niche. In peripheral nerve injuries, especially in neurotmesis, this microenvironment cannot be fully rescued even after surgically binding severed nerve endings together. The composite biomaterials and combined cellular therapies approach increases the functionality and applicability of materials in terms of various properties such as biodegradability, biocompatibility, and processability. Accordingly, this study aims to demonstrate the preparation and use of graphene-based biohybrid hydrogel patterning and to examine the differentiation efficiency of stem cells into nerve cells, which can be an effective solution in nerve regeneration.en_US
dc.identifier.citationYıldız, A. P. Z., Darıcı, H., Yavuz, B., Abamor, E. S., Özdemir, C., Yasin, M. E., ... & Karaöz, E. (2022). Preparation and characterization of graphene-based 3D biohybrid hydrogel bioink for peripheral neuroengineering. Journal of visualized experiments: JoVE,(183).en_US
dc.identifier.issue183en_US
dc.identifier.scopus2-s2.0-85131222251
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://hdl.handle.net/20.500.12939/2480
dc.identifier.wosWOS:000810986100003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYavuz, Burçak
dc.language.isoen
dc.publisherJoveen_US
dc.relation.ispartofJournal of Visualized Experiments
dc.relation.isversionof10.3791/63622en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeuroengineeringen_US
dc.subjectBiocompatible Materialsen_US
dc.subjectGraphiteen_US
dc.subjectHumansen_US
dc.subjectHydrogelsen_US
dc.subjectPeripheral Nerve Injuriesen_US
dc.subjectTissue Scaffoldsen_US
dc.titlePreparation and characterization of graphene-based 3D biohybrid hydrogel bioink for peripheral neuroengineering
dc.typeArticle

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