Follicular fluid cerebellin and betatrophin regulate the metabolic functions of growing follicles in polycystic ovary syndrome

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dc.contributor.authorErşahin, Aynur Adeviye
dc.contributor.authorAcet, Mustafa
dc.contributor.authorErşahin, Suat Süphan
dc.contributor.authorAcet, Tuba
dc.contributor.authorYardım, Meltem
dc.contributor.authorKenanoğlu, Ömer
dc.contributor.authorAydın, Süleyman
dc.date.accessioned2021-05-15T12:36:42Z
dc.date.available2021-05-15T12:36:42Z
dc.date.issued2017
dc.departmentTıp Fakültesien_US
dc.description.abstractObjective: The aim of this study was to assess the changes of follicular fluid (FF) and serum levels of cerebellin precursor protein 1 (cbln1) and betatrophin in patients with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) with a gonadotropin-releasing hormone (GnRH) antagonist protocol. Methods: Twenty infertile women with PCOS and 20 control women diagnosed as poor responders undergoing ovarian stimulation with a GnRH antagonist were included. Blood samples were obtained during ovum pick-up. Follicular fluid from a dominant follicle was collected from the subjects. Using enzyme-linked immunosorbent assays, FF and serum levels of cblnl and betatrophin were measured in both groups of participants. Metabolic and hormonal parameters were also determined and correlated with each other. Results: Both groups of women had similar serum and FF betatrophin levels (55.0 +/- 8.9 ng/mL vs. 53.1 +/- 10.3 ng/mL, p = 0.11). The serum and FF betatrophin levels of poor responders were found to be similar (49.9 +/- 5.9 ng/mL vs. 48.9 +/- 10.7 ng/mL, p = 0.22). Conversely, the FF cbln1 levels of PCOS women were found to be significantly higherthan the serum cbln1 levels (589.1 +/- 147.6 ng/L vs. 531.7 +/- 743 ng/L, p < 0.02).The FF cbln1 levels of control participants without PCOS were significantly higher than their serum cbln1 levels (5993 +/- 211.5 ng/L vs. 5253 +/- 87.0 ng/L, p = 0.01). Positive correlations were detected among body mass index, insulin resistance, serum insulin, total testosterone, and betatrophin levels in the PCOS group. Conclusion: Follicular fluid betatrophin and cbln1 concentrations may playa pivotal role on follicular growth in PCOS subjects undergoing IVF/ICSI with an antagonist protocol.en_US
dc.identifier.doi10.5653/cerm.2017.44.1.33
dc.identifier.endpage39en_US
dc.identifier.issn2233-8233
dc.identifier.issn2233-8241
dc.identifier.issue1en_US
dc.identifier.pmid28428942
dc.identifier.scopus2-s2.0-85017526827
dc.identifier.scopusqualityQ2
dc.identifier.startpage33en_US
dc.identifier.urihttps://doi.org/10.5653/cerm.2017.44.1.33
dc.identifier.urihttps://hdl.handle.net/20.500.12939/378
dc.identifier.volume44en_US
dc.identifier.wosWOS:000488230900006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErşahin, Suat Süphan
dc.language.isoen
dc.publisherKorean Soc Reproductive Medicineen_US
dc.relation.ispartofClinical and Experimental Reproductive Medicine-Cerm
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntagonist Protocolen_US
dc.subjectBetatrophinen_US
dc.subjectCerebellinen_US
dc.subjectFollicular Fluiden_US
dc.subjectIntracytoplasmic Sperm Injectionen_US
dc.subjectIn Vitro Fertilizationen_US
dc.subjectPolycystic Ovary Syndromeen_US
dc.titleFollicular fluid cerebellin and betatrophin regulate the metabolic functions of growing follicles in polycystic ovary syndrome
dc.typeArticle

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