Propofol but not dexmedetomidine produce locomotor sensitization via nitric oxide in rats

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dc.contributor.authorUskur, Tuğce
dc.contributor.authorŞenöz, Ayşe Özçetin
dc.contributor.authorCevreli, Burcu
dc.contributor.authorBarlas, Aydın
dc.contributor.authorUzbay, Tayfun
dc.date.accessioned2021-05-15T11:33:25Z
dc.date.available2021-05-15T11:33:25Z
dc.date.issued2021
dc.departmentTıp Fakültesi, Farmakoloji Anabilim Dalıen_US
dc.description.abstractRationale The abused potential of some anesthetics has been debated. Measurement of locomotor sensitization is a better way to detect the neurobehavioral plasticity of addiction. Objectives The present study aims to explore whether propofol and dexmedetomidine are capable of inducing locomotor sensitization. Methods Male Wistar rats (250-300 g) were the subjects (n = 8 for each group). Propofol (20 and 40 mg/kg) and dexmedetomidine (2.5-20 mu g/kg) or saline were injected to rats intraperitoneally (IP), and their locomotor activities were recorded for 15 min. Consequently, L-NAME (30 and 60 mg/kg)-a nitric oxide (NO) inhibitory agent-was injected to rats 30 min before propofol (40 mg/kg) or saline injections, and the locomotor activity was recorded. The process was carried out for 13 days, with 7 sessions applied every other day. Results Dexmedetomidine did not produce any significant locomotor sensitization. While propofol (20 mg/kg) produced a significant locomotor sensitization in the last treatment session (day 13), at the higher dose, it prompted a significant locomotor sensitization from the 3rd treatment session. L-NAME blocked propofol-induced locomotor hyperactivity and sensitization significantly without producing any noteworthy changes on the locomotor activity during the testing period of 13 days when administered alone. Conclusions Our results suggest that propofol but not dexmedetomidine produced a significant locomotor sensitization via central nitrergic system. Dexmedetomidine may have a lesser psychostimulant type addictive potential than propofol. Sensitization development by propofol implies that this drug might be effective on the neuroadaptive processes associated with a stimulant type of dependence.en_US
dc.description.sponsorshipNeuropsychopharmacology Application and Research Center (NPARC) of Uskudar Universityen_US
dc.description.sponsorshipThe authors would like to thank to Dr. Andleeb Shahzadi for her valuable comments on the statistics. The authors are also grateful to the Neuropsychopharmacology Application and Research Center (NPARC) of Uskudar University for supporting this study and providing the technical facilities for the work.en_US
dc.identifier.doi10.1007/s00213-020-05707-5
dc.identifier.endpage577en_US
dc.identifier.issn0033-3158
dc.identifier.issn1432-2072
dc.identifier.issue2en_US
dc.identifier.pmid33169201
dc.identifier.scopus2-s2.0-85095698603
dc.identifier.scopusqualityQ2
dc.identifier.startpage569en_US
dc.identifier.urihttps://doi.org/10.1007/s00213-020-05707-5
dc.identifier.urihttps://hdl.handle.net/20.500.12939/155
dc.identifier.volume238en_US
dc.identifier.wosWOS:000588004500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBarlas, Aydın
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofPsychopharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPropofolen_US
dc.subjectDexmedetomidineen_US
dc.subjectLocomotor Sensitizationen_US
dc.subjectL-NAMEen_US
dc.subjectRat(s)en_US
dc.titlePropofol but not dexmedetomidine produce locomotor sensitization via nitric oxide in rats
dc.typeArticle

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