Evaluation of the first Candida auris isolates reported from Türkiye in terms of identification by various methods and susceptibility to antifungal drugs

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dc.contributor.authorErköse Genç, Gonca
dc.contributor.authorKüçükkaya, Ilvana Caklovica
dc.contributor.authorKomec, Selda
dc.contributor.authorÖnder, İlke Toker
dc.contributor.authorToptaş, Öykü
dc.contributor.authorTeke, Leyla
dc.contributor.authorTuran, Deniz
dc.contributor.authorAygün, Gökhan
dc.contributor.authorGülmez, Dolunay
dc.contributor.authorArıkan Akdağlı, Sevtap
dc.contributor.authorErturan, Zayre
dc.date.accessioned2024-05-06T10:59:16Z
dc.date.available2024-05-06T10:59:16Z
dc.date.issued2024en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri, Tıbbi Mikrobiyoloji Ana Bilim Dalıen_US
dc.description.abstractPurpose: Candida auris is increasingly being isolated from patients all over the world. It has five clades. In this study, it was aimed to compare the results of biochemical tests obtained using different methods and the antifungal susceptibility profiles of C. auris strains isolated from the first seven cases reported in Türkiye, and evaluate whether this information could be useful as preliminary data in determining the clade of strains in centers that lack the opportunity to apply molecular methods. Methods: Identification test results obtained using API ID 32 C, API 20 C AUX, VITEK-2 YST, and MALDI-TOF MS; colony color and morphology on Chromagar Candida, CHROMagar Candida Plus media, and cornmeal-Tween 80 agar; susceptibility to antifungals were tested and compared. Antifungal susceptibility test was studied using microdilution method according to the recommendations of EUCAST. Additionally, a pilot study was conducted to investigate the value of CHROMagar Candida Plus. Results: All seven strains were identified as Lachancea kluyveri with API ID 32 C, Rhodotorula glutinis; Cryptococcus neoformans with API 20 C AUX, and C. auris with both VITEK-2 YST and MALDI-TOF MS. MIC values for fluconazole were very high (≥64 mg/L) for all seven strains. It was observed that 11 (37.9%) of 29 Candida parapsilosis strains formed colonies with morphology similar to C. auris on CHROMagar Candida Plus medium, leading to false positivity. Conclusions: Although there have been many isolations of C. auris in our country in recent years, clade distribution of only a small number of strains is known yet. In this study, when the biochemical properties and antifungal susceptibility profiles of the seven strains were evaluated, it was concluded that they exhibited some characteristics compatible with clade I. It was also observed that strains 1 and 2 may belong to a different clade.en_US
dc.identifier.citationErköse Genç, G., Küçükkaya, I. C., Komec, S., Önder, İ. T., Toptaş, Ö., Teke, L., Turan, D., Aygün, G., Gülmez, D., Arıkan Akdağlı, S., Erturan, Z. (2024). Evaluation of the first Candida auris isolates reported from Türkiye in terms of identification by various methods and susceptibility to antifungal drugs .Indian Journal of Medical Microbiology, 49. 10.1016/j.ijmmb.2024.100594en_US
dc.identifier.issn0255-0857
dc.identifier.issn1998-3646
dc.identifier.scopus2-s2.0-85191144603
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://hdl.handle.net/20.500.12939/4675
dc.identifier.volume49en_US
dc.identifier.wosWOS:001233981200001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorToptaş, Öykü
dc.language.isoen
dc.relation.ispartofIndian Journal of Medical Microbiology
dc.relation.isversionof10.1016/j.ijmmb.2024.100594en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntifungal susceptibilityen_US
dc.subjectCHROMagar Candida plusen_US
dc.subjectCandida aurisen_US
dc.subjectCandida parapsilosisen_US
dc.subjectIdentificationen_US
dc.titleEvaluation of the first Candida auris isolates reported from Türkiye in terms of identification by various methods and susceptibility to antifungal drugs
dc.typeArticle

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