A Cross-sectional Analysis of Immunological and Hematological Parameters in Patients With Chronic Opioid Use

Basit Öğe Kaydı
dc.contributor.authorErgelen, Mine
dc.contributor.authorUsta Sağlam, Nazife Gamze
dc.contributor.authorArpacıoğlu, Mahmut Selim
dc.contributor.authorYalçın, Murat
dc.contributor.authorİzci, Filiz
dc.date.accessioned2025-08-14T17:46:23Z
dc.date.available2025-08-14T17:46:23Z
dc.date.issued2025
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground and Aim: Previous research has recognized the dual role of opioids [agonists at μ-opioid receptors (MOP-r agonists)] in modulating immunity and neuroinflammation in individuals with opioid use disorder (OUD). This cross-sectional study investigates the interplay between chronic use of MOP-r agonists and inflammatory parameters in individuals with OUD, with the goal of providing insights into the relationship between immunological responses and OUD. Materials and Methods: A cohort of 129 patients with OUD seeking treatment at an addiction detoxification center underwent detailed clinical assessments. Blood samples were collected for analyses of serum alanine aminotransferase, aspartate aminotransferase, and C-reactive protein levels, and a complete blood count. Participants were categorized into inflammation and noninflammation groups based on C-reactive protein levels. Hematological and inflammation indices, along with pain severity, were compared between these groups. Results: Significant differences were observed between the inflammation and noninflammation groups on variables such as duration of MOP-r agonist intake, daily buprenorphine/naloxone dose, consumption route, severity of withdrawal symptoms, and level of self-reported pain. The inflammation group exhibited higher neutrophil counts and an increased neutrophil-to-lymphocyte ratio. The binary logistic regression models revealed that self-reported pain level, daily buprenorphine/naloxone dosage, Beck Depression Inventory scores, and age were significant predictors of inflammation. Conclusions: This study contributes to our understanding of OUD as a chronic inflammatory condition, shedding light on the intricate relationships between MOP-r agonist addiction, inflammatory responses, and withdrawal-related parameters. The findings offer valuable perspectives on effective management, emphasizing the need for further research in diverse populations to enhance understanding of this complex condition.
dc.identifier.citationErgelen, M., Sağlam, N. G. U., Arpacioğlu, M. S., Yalçin, M., & İzci, F. (2025). A Cross-sectional Analysis of Immunological and Hematological Parameters in Patients With Chronic Opioid Use. Journal of Psychiatric Practice®, 31(3), 116-124. 10.1097/PRA.0000000000000861
dc.identifier.doi10.1097/PRA.0000000000000861
dc.identifier.endpage124
dc.identifier.issn1527-4160
dc.identifier.issn1538-1145
dc.identifier.issue3
dc.identifier.pmid40440667
dc.identifier.scopus2-s2.0-105007048426
dc.identifier.scopusqualityQ3
dc.identifier.startpage116
dc.identifier.urihttps://hdl.handle.net/20.500.12939/5920
dc.identifier.volume31
dc.identifier.wosWOS:001498759900001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorArpacıoğlu, Mahmut Selim
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofJournal of Psychiatric Practice
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectC-reactive protein
dc.subjectinflammation
dc.subjectneutrophil-to-lymphocyte ratio
dc.subjectopioid dependence
dc.subjectopioid use disorder
dc.titleA Cross-sectional Analysis of Immunological and Hematological Parameters in Patients With Chronic Opioid Use
dc.typeArticle

Dosyalar

Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

PubMed İndeksli Yayınlar Koleksiyonu
Dahili Tıp Bilimleri Bölümü Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu