Formulating and characterizing an exosome-based dopamine carrier system

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dc.contributor.authorYavuz, Burçak
dc.contributor.authorDarici, Hakan
dc.contributor.authorZorba Yildiz, Aslı Pınar
dc.contributor.authorAbamor, Emrah Şefik
dc.contributor.authorTopuzoğullari, Murat
dc.contributor.authorBağirova, Melahat
dc.contributor.authorKaraoz, Erdal
dc.contributor.authorAllahverdiyev, Adile
dc.date.accessioned2022-05-05T07:04:38Z
dc.date.available2022-05-05T07:04:38Z
dc.date.issued2022en_US
dc.departmentAltınbaş Üniversitesien_US
dc.description.abstractExosomes between 40 and 200 nm in size constitute the smallest subgroup of extracellular vesicles. These bioactive vesicles secreted by cells play an active role in intercellular cargo and communication. Exosomes are mostly found in body fluids such as plasma, cerebrospinal fluid, urine, saliva, amniotic fluid, colostrum, breast milk, joint fluid, semen, and pleural acid. Considering the size of exosomes, it is thought that they may play an important role in central nervous system diseases because they can pass through the blood-brain barrier (BBB). Hence, this study aimed to develop an exosome-based nanocarrier system by encapsulating dopamine into exosomes isolated from Wharton's jelly mesenchymal stem cells (WJ-MSCs). Exosomes that passed the characterization process were incubated with dopamine. The dopamine-loaded exosomes were recharacterized at the end of incubation. Dopamine-loaded exosomes were investigated in drug release and cytotoxicity assays. The results showed that dopamine could be successfully encapsulated within the exosomes and that the dopamine-loaded exosomes did not affect fibroblast viability.en_US
dc.identifier.citationYavuz, B., Darici, H., Yildiz, A. P. Z., Abamor, E. Ş., Topuzoğullari, M., Bağirova, M., ... & Karaoz, E. (2022). Formulating and Characterizing an Exosome-based Dopamine Carrier System. Journal of visualized experiments: JoVE, (182).en_US
dc.identifier.issn1940087X
dc.identifier.issue182en_US
dc.identifier.scopus2-s2.0-85128792693
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://hdl.handle.net/20.500.12939/2404
dc.identifier.wosWOS:000810726600012
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYavuz, Burçak
dc.language.isoen
dc.publisherJournal of Visualized Experimentsen_US
dc.relation.ispartofJournal of Visualized Experiments
dc.relation.isversionof10.3791/63624en_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDopamineen_US
dc.subjectDopamine Plasma Membrane Transport Proteinsen_US
dc.subjectExosomesen_US
dc.titleFormulating and characterizing an exosome-based dopamine carrier system
dc.typeArticle

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