Interleukin-8 (IL-8) levels in gingival crevicular fluid during root canal treatment of molar teeth with symptomatic irreversible pulpitis: impact of varying sodium hypochlorite concentrations

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dc.contributor.authorÖzlek, Esin
dc.contributor.authorKadı, Gizem
dc.contributor.authorShoshaa, Nasser
dc.contributor.authorSaed, Yusuf
dc.contributor.authorMeydan, İsmet
dc.date.accessioned2024-04-03T06:36:56Z
dc.date.available2024-04-03T06:36:56Z
dc.date.issued2024en_US
dc.departmentFakülteler, Diş Hekimliği Fakültesi, Endodonti Ana Bilim Dalıen_US
dc.description.abstractBackground: The aim of this study was to evaluate the effect of the use of different NaOCl concentrations (1%, 2.5%, and 5.25%) during root canal treatment of molar teeth with symptomatic irreversible pulpitis on the change of the IL-8 level in gingival crevicular fluid (GFC). Methods: GCF sampling was performed on experimental tooth with irreversible pulpitis before and after treatment and also contralateral healthy tooth of 54 patients. The patients were divided into three groups according to concentration of NaOCl solution (n = 18); 1%, 2.5%, and 5.25% NaOCl solution. GCF sampling from experimental teeth was repeated one week after root canal treatment. Statistical analysis was performed using Mann-Whitney U, Wilcoxon test, one-way ANOVA and Pearson correlation analysis. Results: There was a significant correlation between IL-8 levels in GCF samples taken from teeth with pulpitis before treatment and from healthy contralateral teeth (p = .000). Furthermore, the pretreatment IL-8 level was significantly higher than the posttreatment IL-8 level(p < .05). The effect of the NaOCl concentration on the change in IL-8 level betweeen pre and post treatment was not found statistically significant (p > .05). Conclusions: The use of NaOCl during root canal treatment can effectively reduce the levels of IL-8 in GCF and improve clinical outcomes. Trial registration: This study was registred in the Institutional Review Board and the Ethics Committee of the University (No:11) on 15/12/2021.en_US
dc.identifier.citationÖzlek, E., Kadı, G., Shoshaa, N., Saed, Y., Meydan, İ. (2024). Interleukin-8 (IL-8) levels in gingival crevicular fluid during root canal treatment of molar teeth with symptomatic irreversible pulpitis: impact of varying sodium hypochlorite concentrations. BMC Oral Health, 24(1). 10.1186/s12903-024-04128-6en_US
dc.identifier.issn1472-6831
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85188954179
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://hdl.handle.net/20.500.12939/4664
dc.identifier.volume24en_US
dc.identifier.wosWOS:001195487700003
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKadı, Gizem
dc.language.isoen
dc.relation.ispartofBMC Oral Health
dc.relation.isversionof10.1186/s12903-024-04128-6en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGingival cervicular fluiden_US
dc.subjectInterleukin-8en_US
dc.subjectSodium hypochloriteen_US
dc.titleInterleukin-8 (IL-8) levels in gingival crevicular fluid during root canal treatment of molar teeth with symptomatic irreversible pulpitis: impact of varying sodium hypochlorite concentrations
dc.typeArticle

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