Thin endometrium restricts peri-ovulatory physiological transition between anti-adhesive and adhesive receptivity modulators

dc.contributor.authorÇelik, Önder
dc.contributor.authorErşahin, Aynur
dc.contributor.authorGüngör, Nur D.
dc.contributor.authorUluğ, Ulun
dc.contributor.authorÇelik, Nilüfer
dc.contributor.authorYardım, Meltem
dc.contributor.authorTektemur, Ehmet
dc.contributor.authorDalkılıç, Semih
dc.contributor.authorKuloğlu, Tuncay
dc.contributor.authorErşahin, Suat Süphan
dc.contributor.authorÇelik, Sudenaz
dc.contributor.authorAkkoç, Ramazan F.
dc.date.accessioned2025-08-14T17:34:10Z
dc.date.available2025-08-14T17:34:10Z
dc.date.issued2025
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü,Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.descriptionArticle number : 104697 CODEN : RBOEA
dc.description.abstractResearch question: Does endometrial thinning affect the physiological transition of the endometrium from a non-receptive to a receptive state? Design: Fifty-eight women who underwent total embryo freezing were divided into three groups according to their endometrial thickness (EMT): group 1, EMT ≤ 7 mm; group 2, 7 mm < EMT ≤ 10 mm; and group 3, EMT > 10 mm. Group 1 was considered as having a thin EMT and groups 2 and 3 as a normal EMT. Endometrial sampling was performed at the time of oocyte retrieval. Anti-adhesive podocalyxin (PDX), adhesive homeobox A10 and A11 (HOXA10, HOXA11) and leukaemia inhibitory factor (LIF) mRNA, proinflammatory cytokines, oxidative stress markers and collagen deposition were determined. Results: Compared with groups 2 and 3, the relative expression of HOXA10, HOXA11 and LIF mRNA was down-regulated in group 1 (all P < 0.001), while PDX levels significantly increased (P < 0.001). The nuclear factor-κB, long pentraxin 3 (PTX3), tumour necrosis factor-α and total oxidant status of the thin endometrium group were significantly higher than those of participants with normal endometrium (all P < 0.001), while total antioxidant status was significantly lower (P < 0.001). The histoscore values for PTX3, PDX and Masson's trichrome were significantly higher in the thin endometrium group (P < 0.001 for each). Each millimetre increase in EMT decreased the risk of down-regulation of adhesive receptivity genes. The adjusted odds ratio for PDX was 1.69, representing a 69% increase in PDX expression. Conclusion: Endometrial thinning causes defective expression of anti-adhesive and adhesive receptivity modulators, restricting the transition of the endometrium from a non-receptive to a receptive state.
dc.identifier.citationÇelik, O., Erşahin, A., Güngör, N. D., Uluğ, U., Çelik, N., Yardım, M., ... & Akkoç, R. F. (2024). Thin endometrium restricts periovulatory physiological transition between anti-adhesive and adhesive receptivity modulators. Reproductive BioMedicine Online, 104697.
dc.identifier.doi10.1016/j.rbmo.2024.104697
dc.identifier.issn1472-6483
dc.identifier.issn1472-6491
dc.identifier.issue2
dc.identifier.pmid40543138
dc.identifier.scopus2-s2.0-105008526671
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/20.500.12939/5888
dc.identifier.volume51
dc.identifier.wosWOS:001519128000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorErşahin, Suat Süphan
dc.language.isoen
dc.publisherReproductive Healthcare Ltd.
dc.relation.ispartofReproductive Biomedicine Online
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAdhesive receptivity genes
dc.subjectAnti-adhesive protein
dc.subjectCollagen deposition
dc.subjectEndometrial thickness
dc.subjectProinflammatory cytokines
dc.subjectRedox balance
dc.titleThin endometrium restricts peri-ovulatory physiological transition between anti-adhesive and adhesive receptivity modulators
dc.typeArticle

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