Epileptic seizure-induced structural and functional changes in rat femur and tibia bone tissues: A fourier transform infrared imaging study

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dc.contributor.authorGarip, Şebnem
dc.contributor.authorŞahin, Deniz
dc.contributor.authorSevercan, Feride
dc.date.accessioned2021-05-15T12:40:56Z
dc.date.available2021-05-15T12:40:56Z
dc.date.issued2013
dc.departmentTıp Fakültesi, Tıbbi Biyokimya Anabilim Dalıen_US
dc.descriptionSahin, Deniz/0000-0002-6752-0065; Severcan, Feride/0000-0002-1717-2517
dc.description.abstractThe disease- and drug- related bone disorders are rapidly increasing in the population. It is previously reported that anti-epileptic drugs (AEDs) may cause osteopenia, osteoporosis, and fractures in epilepsy patients. However, it cannot be determined whether the bone disorders in epileptic patients are due to AED therapy and/or to epilepsy and epileptic seizures. There is no study in the literature which investigates the sole effects of epilepsy and epileptic seizures on bone tissues. The current study provides the first report on determination of the possible effects of epilepsy and epileptic seizures on long bone tissues. Wistar Albino Glaxo/Rijswijk rats, which are accepted as genetic rat models for human absence epilepsy, were compared with the healthy Wistar rats to get information about the sole effects of epilepsy and epileptic seizures on bones. Cortical regions of tibia and femur bones were studied by Fourier transform infrared microspectroscopy (FTIRM). According to FTIRM parameters, variation on bone mineral and matrix composition, including decreased mineral content, decreased collagen cross-links, increased carbonate substitution, and larger crystals in epileptic group compared to the healthy one, show severe effects of epilepsy and seizures on bone tissues for the first time. (C) 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)en_US
dc.description.sponsorshipMiddle East Technical University (METU) [BAP-07.02.2009.00.01]en_US
dc.description.sponsorshipWe are grateful to Dr. Gul Ilbay for her help in animal studies. This study was supported by Middle East Technical University (METU) research fund BAP-07.02.2009.00.01.en_US
dc.identifier.doi10.1117/1.JBO.18.11.111409
dc.identifier.issn1083-3668
dc.identifier.issn1560-2281
dc.identifier.issue11en_US
dc.identifier.pmid23887385
dc.identifier.scopus2-s2.0-84887944465
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1117/1.JBO.18.11.111409
dc.identifier.urihttps://hdl.handle.net/20.500.12939/713
dc.identifier.volume18en_US
dc.identifier.wosWOS:000328895100014
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGarip, Şebnem
dc.language.isoen
dc.publisherSpie-Soc Photo-Optical Instrumentation Engineersen_US
dc.relation.ispartofJournal of Biomedical Optics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAbsence Epilepsy Rat Model Boneen_US
dc.subjectBone Disordersen_US
dc.subjectFourier Transform Infrared Imagingen_US
dc.subjectMineral Contenten_US
dc.subjectCarbonate Substitutionen_US
dc.subjectCollagen Cross-Linksen_US
dc.subjectCrystallinityen_US
dc.titleEpileptic seizure-induced structural and functional changes in rat femur and tibia bone tissues: A fourier transform infrared imaging study
dc.typeArticle

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