Human papillomavirus prevalence and genotype distribution among Turkish women with or without cervical lesion

Basit Öğe Kaydı
dc.contributor.authorDemirci, Mehmet
dc.contributor.authorGüzel, Aylin Dağ
dc.contributor.authorErşahin, Aynur Adeviye
dc.contributor.authorYorulmaz, Eda
dc.contributor.authorErşahin, Suat Süphan
dc.contributor.authorBorsa, Barış Ata
dc.date.accessioned2021-05-15T12:41:34Z
dc.date.available2021-05-15T12:41:34Z
dc.date.issued2018
dc.departmentTıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalıen_US
dc.descriptionDemirci, Mehmet/0000-0001-9670-2426; DAG GUZEL, AYLIN/0000-0002-5774-9712
dc.description.abstractContext: Human papillomavirus (HPV) infection is the main cause of cervical cancer, but the risk is associated with the various HPV genotypes which may be found in women with or without clinical findings. Aims: We aimed to identify HPV prevalence and genotype distribution in women with or without cervical lesions admitted to Gynaecology and Obstetrics Clinics of one of the largest private hospitals in Istanbul between 2013 and 2017. Subjects and Methods: In the present study, cervical cytobrush samples collected from 2464 women with different cytological conditions, and investigated for the presence of HPV, and the different genotypes. Results were evaluated based on the HPV positivity in different cytological findings, and ages. Furthermore, distribution of high-risk (HR) and low-risk (LR) genotypes in different groups was investigated. Results: Among all participants, 1925 (78.1%) was with the normal cytological condition, 354 (14.4%) with ASC-US; 151 (6.1%) with low-grade squamous intraepithelial lesion (LSIL), and 34 (1.4%) with high-grade squamous intraepithelial lesion (HSIL). Our results showed that 649 out of 2464 patients (26.3%) were positive, and 1815 (73.7%) were negative for the presence of HPV. Among 649 positive patients, 223 (34.3%) were found positive for more than one genotype. HPV 16 was found the most common HR-HPV type in ASC-US and LSIL whereas HPV 18 was the most common in HSIL. HPV 6 was found the most common LR-HPV type in ASC-US and LSIL whereas HPV 11 was the most common in HSIL. 26.9% of women <50 years old, and 22.3% of women >= 50 years old was positive for HPV. The most common HR-HPV genotype was 16 in both groups with (19%) or without (17%) abnormal cytology. Conclusions: We concluded that HPV prevalence and genotype distribution in women with or without clinical findings is an important predictor of cervical cancer.en_US
dc.identifier.doi10.4103/ijmm.IJMM_18_232
dc.identifier.endpage521en_US
dc.identifier.issn0255-0857
dc.identifier.issn1998-3646
dc.identifier.issue4en_US
dc.identifier.pmid30880699
dc.identifier.scopus2-s2.0-85063297691
dc.identifier.scopusqualityQ2
dc.identifier.startpage517en_US
dc.identifier.urihttps://doi.org/10.4103/ijmm.IJMM_18_232
dc.identifier.urihttps://hdl.handle.net/20.500.12939/822
dc.identifier.volume36en_US
dc.identifier.wosWOS:000462457300010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErşahin, Suat Süphan
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofIndian Journal of Medical Microbiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCervical Lesionen_US
dc.subjectGenotypeen_US
dc.subjectHuman Papillomavirusen_US
dc.titleHuman papillomavirus prevalence and genotype distribution among Turkish women with or without cervical lesion
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
MEHMET.pdf
Boyut:
509.26 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/ Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Cerrahi Tıp Bilimleri Bölümü Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu