Anthemis tricolor containing unusual totarol with cytotoxic and acetylcholinesterase-inhibitory activity

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dc.contributor.authorYücel Yücel, Yasemin
dc.contributor.authorServi, Hüseyin
dc.contributor.authorPolatoğlu, Kaan
dc.contributor.authorNalbantsoy, Ayşe
dc.date.accessioned2023-12-27T12:59:50Z
dc.date.available2023-12-27T12:59:50Z
dc.date.issued2023en_US
dc.departmentFakülteler, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Kimya Ana Bilim Dalıen_US
dc.description.abstractAnthemis tricolor is an endemic species of Cyprus, and there is very limited information on its chemistry and pharmacological activities. The study aims to identify the in-vitro cytotoxic and acetylcholinesterase activities of Anthemis tricolor. The compounds responsible for the activities were also identified. Potent extracts of A. tricolor were subjected to preparative isolation and spectral structure determination studies. The chloroform extract contained many components, and due to the small quantity of extract available, enough pure compound(s) cannot be obtained for structure determination studies, though the n-hexane extract afforded two known compounds, totarol (1) and taraxasterol (2). The structures of the compounds (1 and 2) were determined by 1H and 13C NMR experiments. The pure compounds were also tested for their acetylcholinesterase inhibitory properties. For compound 1, the IC50 value was found to be 87.88 µg/mL. However, no inhibition was seen for 2. Anthemis tricolor was established to be a valuable source of pharmacologically active compounds and requires further studies.en_US
dc.identifier.citationYücel Yücel, Y., Servi, H., Polatoğlu, K., Nalbantsoy, A. (2023). Anthemis tricolor containing unusual totarol with cytotoxic and acetylcholinesterase-inhibitory activity. Chemistry & Biodiversity, 21(2). 10.1002/cbdv.202300913en_US
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85181669288
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://hdl.handle.net/20.500.12939/4454
dc.identifier.volume21en_US
dc.identifier.wosWOS:001138860200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYücel Yücel, Yasemin
dc.institutionauthorPolatoğlu, Kaan
dc.language.isoen
dc.relation.ispartofChemistry & Biodiversity
dc.relation.isversionof10.1002/cbdv.202300913en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAChEen_US
dc.subjectAnthemis tricoloren_US
dc.subjectCytotoxic activityen_US
dc.subjectTaraxasterolen_US
dc.subjectTotarolen_US
dc.titleAnthemis tricolor containing unusual totarol with cytotoxic and acetylcholinesterase-inhibitory activity
dc.typeArticle

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