Is immunohistochemical galectin-3 expression associated with the epithelial-mesenchymal transition in high- and low-grade invasive urothelial carcinomas of the bladder?

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dc.contributor.authorCin, Merve
dc.contributor.authorAkyıldız İğdem, Ayşenur
dc.contributor.authorBektaş, Sibel
dc.contributor.authorGündoğar, Özgecan
dc.contributor.authorCin, Selçuk
dc.contributor.authorKomut, Neslihan
dc.contributor.authorÇetin, Buğra
dc.date.accessioned2024-11-01T07:13:51Z
dc.date.available2024-11-01T07:13:51Z
dc.date.issued2024en_US
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü,Üroloji Ana Bilim Dalıen_US
dc.description.abstractBackground/Objectives: Bladder cancer, predominantly urothelial carcinoma, is an important malignancy of the urinary system. Despite the same histologic grade and stage, some patients seem to have a worse prognosis. In this context, the epithelial-mesenchymal transition (EMT), characterized by the loss of E-cadherin and gain of vimentin expression, is an important process in tumor progression. Galectin-3, a lactose-binding protein involved in various cellular processes, has been associated with increased tumor cell migration, invasion, and treatment resistance. Methods: In this study, 223 bladder cancer cases were examined, and E-cadherin, vimentin, and galectin-3 expression was evaluated by immunohistochemical staining in tumor budding areas and invasive components. These markers were also correlated with clinicopathological parameters, including tumor grade and stage. Results: The results indicated a significant decrease in E-cadherin expression and an increase in vimentin staining in higher-grade and higher-stage tumors, supporting EMT involvement. Galectin-3 expression was notably higher in T1 high-grade tumors but decreased in T2 stage tumors. Despite this, no significant correlation was found between galectin-3 and E-cadherin or vimentin, suggesting a complex role of galectin-3 in EMT. Conclusions: High galectin-3 expression in T1 high-grade tumors highlights its potential role in early tumor progression and as a therapeutic target. However, the decrease in its expression in advanced stages underscores the need for further research to understand its multifaceted involvement in bladder cancer. These findings suggest that while galectin-3 may contribute to the EMT and early tumor progression, its exact role and potential as a therapeutic target require more detailed investigation.en_US
dc.identifier.citationCin, M., Akyıldız İğdem, A., Bektaş, S., Gündoğar, Ö., Cin, S., Komut, N., Çetin, B. (2024). Is immunohistochemical galectin-3 expression associated with the epithelial-mesenchymal transition in high- and low-grade invasive urothelial carcinomas of the bladder?. Diagnostics (Basel), 14(20). 10.3390/diagnostics14202270en_US
dc.identifier.issn2075-4418
dc.identifier.issue20en_US
dc.identifier.scopus2-s2.0-85207496590
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://hdl.handle.net/20.500.12939/4949
dc.identifier.volume14en_US
dc.identifier.wosWOS:001341584800001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇetin, Buğra
dc.language.isoen
dc.relation.ispartofDiagnostics (Basel)
dc.relation.isversionof10.3390/diagnostics14202270en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectE-cadherinen_US
dc.subjectBladder canceren_US
dc.subjectEpithelial–Mesenchymal Transition (EMT)en_US
dc.subjectGalectin-3en_US
dc.subjectVimentinen_US
dc.titleIs immunohistochemical galectin-3 expression associated with the epithelial-mesenchymal transition in high- and low-grade invasive urothelial carcinomas of the bladder?
dc.typeArticle

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