A meta-analysis assessing the prevalence of drug-drug interactions among hospitalized patients

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dc.contributor.authorAksoy, Nilay
dc.contributor.authorÖztürk, Nur
dc.date.accessioned2023-09-21T05:17:22Z
dc.date.available2023-09-21T05:17:22Z
dc.date.issued2023en_US
dc.departmentFakülteler, Eczacılık Meslek Bilimleri Bölümü, Klinik Eczacılık Ana Bilim Dalıen_US
dc.description.abstractPurpose: Drug-drug interactions (DDIs), particularly in hospitalized patients can result in adverse drug events and unfavorable health consequences. The aim of this meta-analysis is to provide up-to-date evidence on the prevalence of clinically evident adverse drug events due to DDIs in hospitalized patients. Methods: Data from Scopus, PubMed, Cochrane and Web of Science were extracted using these keywords (Drug interaction/drug-drug interactions, Hospital/ hospitals, Adverse drug event, Hospitalized patients, inpatient, Department, Hospital stay, Harm, Mortality, death). The studies that include Observational studies on hospitalized patients, reporting potential DDIs using an electronic database, and reporting the clinically observed adverse drug interactions (ADI) through symptoms, signs or Laboratory tests are included. Using Open meta-Software (version 12.11.14), the incidence of clinically evident DDIs among hospitalized patients was determined and shown in a forest plot. Results: Only 15 of the 8261 articles found through a literature search met the inclusion criteria and reported the desired outcome. The pooled prevalence of potential drug-drug interactions is 64.9% (CI 95% 0.618-0.736). While clinically evident DDIs have a pooled frequency of 17.17% (CI 95% 0.133-0.256). Conclusion: The issue of DDIs remains a significant concern in hospitalized patients, with a notable rise in their prevalence. This meta-analysis encompassed a greater quantity of studies and demonstrated a heightened proportion of drug-drug interaction prevalence in comparison to the percentages reported in the previously published meta-analysis.en_US
dc.identifier.citationAksoy, N., & Ozturk, N. (2023). A meta‐analysis assessing the prevalence of drug–drug interactions among hospitalized patients. Pharmacoepidemiology and Drug Safety, 32(12), 1319-1330.en_US
dc.identifier.endpage1330en_US
dc.identifier.issn1053-8569
dc.identifier.issn1099-1557
dc.identifier.issue12en_US
dc.identifier.scopus2-s2.0-85170683236
dc.identifier.scopusqualityQ2
dc.identifier.startpage1319en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12939/4049
dc.identifier.volume32en_US
dc.identifier.wosWOS:001065022300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAksoy, Nilay
dc.language.isoen
dc.relation.ispartofPharmacoepidemiology and Drug Safety
dc.relation.isversionof10.1002/pds.5691en_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdverse Drug Eventsen_US
dc.subjectDrug-Drug Interactionsen_US
dc.subjectInpatienten_US
dc.subjectPatientsen_US
dc.subjectPrevalenceen_US
dc.titleA meta-analysis assessing the prevalence of drug-drug interactions among hospitalized patients
dc.typeReview Article

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