The investigation of the molecular changes during lipopolysaccharide-induced systemic inflammation on rat hippocampus by using FTIR spectroscopy

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dc.contributor.authorÇakmak-Arslan, Gülgün
dc.contributor.authorKaya, Yıldıray
dc.contributor.authorMamuk, Soner
dc.contributor.authorAkarsu, Eyüp Sabri
dc.contributor.authorSevercan, Feride
dc.date.accessioned2024-04-03T06:38:44Z
dc.date.available2024-04-03T06:38:44Z
dc.date.issued2024en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri, Biyofizik Ana Bilim Dalıen_US
dc.description.abstractThe aim of this study is to reveal the molecular changes accompanying the neuronal hyper-excitability during lipopolysaccharide (LPS)-induced systemic inflammation on rat hippocampus using Fourier transform infrared (FTIR) spectroscopy. For this aim, the body temperature of Wistar albino rats administered LPS or saline was recorded by radiotelemetry. The animals were decapitated when their body temperature began to decrease by 0.5°C after LPS treatment and the hippocampi of them were examined by FTIR spectroscopy. The results indicated that systemic inflammation caused lipid peroxidation, an increase in the amounts of lipids, proteins and nucleic acids, a decrease in membrane order, an increase in membrane dynamics and changes in the secondary structure of proteins. Principal component analysis successfully separated control and LPS-treated groups. In conclusion, significant structural, compositional and functional alterations occur in the hippocampus during systemic inflammation and these changes may have specific characteristics which can lead to neuronal hyper-excitability.en_US
dc.identifier.citationÇakmak-Arslan, G., Kaya, Y., Mamuk, S., Akarsu, E. S., Severcan, F. (2024). The investigation of the molecular changes during lipopolysaccharide-induced systemic inflammation on rat hippocampus by using FTIR spectroscopy. Journal of Biophotonics, 17(6). 10.1002/jbio.202300541en_US
dc.identifier.issn1864-063X
dc.identifier.issn1864-0648
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85189509448
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/20.500.12939/4666
dc.identifier.volume17en_US
dc.identifier.wosWOS:001190848300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSevercan, Feride
dc.language.isoen
dc.relation.ispartofJournal of Biophotonics
dc.relation.isversionof10.1002/jbio.202300541en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFourier transform infrared (FTIR) spectroscopyen_US
dc.subjectHippocampusen_US
dc.subjectLipid structureen_US
dc.subjectLipopolysaccharide (LPS)en_US
dc.subjectNeuronal excitabilityen_US
dc.subjectProtein structureen_US
dc.subjectSystemic inflammationen_US
dc.titleThe investigation of the molecular changes during lipopolysaccharide-induced systemic inflammation on rat hippocampus by using FTIR spectroscopy
dc.typeArticle

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