Evaluating the Antibiofilm Effects of Antibiotics on Staphylococcus Species from Pediatric Hematology-Oncology Patients

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dc.contributor.authorVatansever, Cansu
dc.contributor.authorAksoy, Nilay
dc.contributor.authorAdaklı Aksoy, Başak
dc.contributor.authorFışgın, Tunç
dc.date.accessioned2025-07-31T11:22:09Z
dc.date.available2025-07-31T11:22:09Z
dc.date.issued2025
dc.departmentFakülteler, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Botanik Ana Bilim Dalı
dc.description.abstractBiofilms are microbial communities and occur on different medical devices such as catheters. The formation of bacterial biofilms on medical devices leads to indwelling medical device-related infections. Since biofilm bacteria are more resistant to antibiotics than planktonic bacteria, using these antibiotics in indwelling medical device-related infections causes recurrence of infections, treatment failure, and death. Minimum inhibitory concentration (MIC) is an important reference in treating acute infections caused by planktonic bacteria. However, MIC is ineffective in indwelling medical device-related infections caused by biofilm bacteria. The study aims to demonstrate the necessity and development of effective and standard methods such as minimum biofilm prevention concentration, minimum biofilm inhibitory concentration, and minimum biofilm eradication concentration in the case of indwelling medical device-related infection. The study was conducted with 10 isolates of Staphylococcus species from patients who developed infections in the Pediatric Hematology-Oncology Department at Medical Park Bahcelievler Hospital. According to the study results, even if planktonic bacteria are sensitive to antibiotics, they can become resistant to this antibiotic when they are in a biofilm (p < 0.05, Crosstab). Also, inhibiting the growth of planktonic bacteria does not prevent biofilm formation. The study additionally revealed that inhibiting and eradicating biofilm is more difficult than preventing biofilm formation (p < 0.05).
dc.identifier.citationVatansever, C., Aksoy, N., Adaklı Aksoy, B., Fışgın, T. (2025). Evaluating the Antibiofilm Effects of Antibiotics on Staphylococcus Species from Pediatric Hematology–Oncology Patients. Microbial Drug Resistance, 31(6), 178-188. 10.1089/mdr.2025.0006
dc.identifier.doi10.1089/mdr.2025.0006
dc.identifier.endpage188
dc.identifier.issn1076-6294
dc.identifier.issn1931-8448
dc.identifier.issue6
dc.identifier.pmid40340597
dc.identifier.scopus2-s2.0-105004905772
dc.identifier.scopusqualityQ2
dc.identifier.startpage178
dc.identifier.urihttps://hdl.handle.net/20.500.12939/5811
dc.identifier.volume31
dc.identifier.wosWOS:001484631800001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorVatansever, Cansu
dc.institutionauthorAksoy, Nilay
dc.institutionauthorAdaklı Aksoy, Başak
dc.institutionauthorFışgın, Tunç
dc.language.isoen
dc.relation.bapinfo:eu-repo/grantAgreement/BAP/Altinbas/PB2018-GUEZ-ECZ-1
dc.relation.ispartofMicrobial Drug Resistance
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectantibiotic resistance in biofilm
dc.subjectbiofilm inhibition
dc.subjectbiofilm prevention
dc.subjectindwelling medical device-related infections
dc.subjectpediatric hematology-oncology
dc.subjectStaphylococcus spp
dc.titleEvaluating the Antibiofilm Effects of Antibiotics on Staphylococcus Species from Pediatric Hematology-Oncology Patients
dc.typeArticle

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