Genome resequencing and comparative analysis of Streptococcus mutans in adults with high and low caries risk

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dc.contributor.authorYıldırım Üçüncü, Merve
dc.contributor.authorÜçüncü, Musa Kazım
dc.contributor.authorKaracan, İlker
dc.contributor.authorTopçuoğlu, Nurşen
dc.date.accessioned2025-05-12T08:32:02Z
dc.date.available2025-05-12T08:32:02Z
dc.date.issued2025
dc.departmentFakülteler, Diş Hekimliği Fakültesi, Restoratif Diş Tedavisi Ana Bilim Dalı
dc.description.abstractStreptococcus mutans, is considered the main microbial etiological agent of dental caries, therefore it has been proposed as a useful predictor of caries risk as well as a target for caries prevention strategies. We aimed to compare the genomic characteristics of S. mutans strains isolated from individuals with high and low caries risk, in order to determine their genotypic features related to dental caries in adults. A total of 25 S. mutans isolates, obtained from the saliva of 13 volunteers with high dental caries activity and 12 caries-free individuals, were analysed using whole-genome sequencing techniques. A total of 2904 protein-coding gene sequences were detected as a result of the pan-genome analysis. The number of core genes detected in all genomes sequenced in the study was found to be 1563. A total of 50584 mutations were detected using ATCC 25175 strain as a reference. This is a large genome dataset of 25 S. mutans strains which can be further used for all S. mutans genome analysis.
dc.identifier.citationUcuncu, M. Y., Ucuncu, M. K., Karacan, I., & Topcuoglu, N. (2025). Genome resequencing and comparative analysis of Streptococcus mutans in adults with high and low caries risk. Scientific data, 12(1), 313.
dc.identifier.doi10.1038/s41597-025-04399-w
dc.identifier.issn2052-4463
dc.identifier.issue1
dc.identifier.pmid39984482
dc.identifier.scopus2-s2.0-85219642526
dc.identifier.urihttps://hdl.handle.net/20.500.12939/5740
dc.identifier.volume12
dc.identifier.wosWOS:001427694000006
dc.identifier.wosqualityQ1
dc.indekslendigikaynakPubMed
dc.institutionauthorÜçüncü, Musa Kazım
dc.language.isoen
dc.relation.ispartofScientific Data
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectStreptococcus mutans
dc.subjectDental caries
dc.subjectCaries prevention
dc.titleGenome resequencing and comparative analysis of Streptococcus mutans in adults with high and low caries risk
dc.typeArticle

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