Development of phytotherapeutic nanoformulation containing Gypsophila eriocalyx and its evaluation as a candidate formulation for osteoporosis treatment on human bone marrow stem cells

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dc.contributor.authorKaymak, Sibel
dc.contributor.authorKurtur, Ozan Barış
dc.contributor.authorGök, Bahar
dc.contributor.authorBudama-Kılınç, Yasemin
dc.contributor.authorKeçel-Gündüz, Serda
dc.contributor.authorNath, Ebru Özdemir
dc.contributor.authorKartal, Murat
dc.date.accessioned2024-09-02T06:39:19Z
dc.date.available2024-09-02T06:39:19Z
dc.date.issued2024en_US
dc.departmentFakülteler, Eczacılık Meslek Bilimleri Bölümü, Farmasötik Botanik Ana Bilim Dalıen_US
dc.description.abstractIntroduction: Osteoporosis, one of the common bone diseases, manifests itself as a decrease in bone mass. Recently, the use of medicinal plants in the search for effective and low-toxicity therapeutics for the prevention or treatment of osteoporosis has become a trending topic. Objective: In this study, we aim to prepare a controlled drug carrier system loaded with Gypsophila eriocalyx to determine its potential for anti-osteoporosis applications. Methods: Gypsophila eriocalyx extract (GEE) was prepared, and components were determined. The molecular interactions of the components with Cathepsin K (CatK), which is used as a target in drug development against osteoporosis, were revealed by in silico molecular docking and MD methods. ADMET profiles were also examined. GEE-loaded chitosan nanoparticles (CNPs) were synthesized. The nanoparticles' morphology, encapsulation efficiency, loading capacity, release profile, average size, polydispersity index, and zeta potentials were determined. The cytotoxic effects of GEE and GEE-loaded CNPs on the L929 and osteogenic proliferation profiles on human bone marrow stem cells (hBMC) were examined. Results: The MD analysis revealed no breaks or atomic changes in the dynamic system, and the docking analysis confirmed the continued interaction of identical residues. It was determined that the GEE-loaded CNP formulation was produced successfully, had no toxic effect on the L929, and had an osteogenic proliferation effect on hBMC. Conclusion: In line with the in vitro and in silico results obtained, it was evaluated that GEE-loaded CNPs can be used as a controlled drug release system as a candidate formulation with phytotherapeutic properties for osteoporosis treatment.q1.en_US
dc.identifier.citationKaymak, S., Kurtur, O. B., Gök, B., Budama-Kılınç, Y., Keçel-Gündüz, S., Nath, E. Ö., Kartal, M. (2024). Development of phytotherapeutic nanoformulation containing Gypsophila eriocalyx and its evaluation as a candidate formulation for osteoporosis treatment on human bone marrow stem cells . Phytochemical analysis. 10.1002/pca.3440en_US
dc.identifier.issn0958-0344
dc.identifier.issn1099-1565
dc.identifier.scopus2-s2.0-85202078363
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://hdl.handle.net/20.500.12939/4813
dc.identifier.wosWOS:001298672900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorNath, Ebru Özdemir
dc.language.isoen
dc.relation.ispartofPhytochemical Analysis
dc.relation.isversionof10.1002/pca.3440en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChitosan nanoparticlesen_US
dc.subjectMedicinal planten_US
dc.subjectMolecular dockingen_US
dc.subjectOsteoporosisen_US
dc.subjectStem cellen_US
dc.titleDevelopment of phytotherapeutic nanoformulation containing Gypsophila eriocalyx and its evaluation as a candidate formulation for osteoporosis treatment on human bone marrow stem cells
dc.typeArticle

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